Studies on the Ethanol, n-Propanol and Isopropanol Solvates of Cortisone Acetate
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概要
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Solvates of cortisone acetate with ethanol, n-propanol and isopropanol were isolated, and their physico-chemical properties were investigated by X-ray powder diffractometry, infrared spectroscopy, differential scanning calorimetry, thermogravimetry, and scanning electron microscopy. Also, the specific surface areas and pore volumes of the desolvated products were measured by the BET method. The combining ratios of the solvates were all determined to be 1 : 1 from the weight change in thermogravimetric curves. From the kinetic analysis of the thermal desolvation, it appeared that the desolvation proceeded in accordance with the mechanism of the two-dimensional growth of nuclei as represented by the Avrami-Erofeev equation. In addition, it was found that the powders recovered by desolvation had fairly large specific surface areas and pore volumes, and were easily divided into fine powders by only slight trituration.
- 公益社団法人日本薬学会の論文
- 1981-10-25
著者
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関口 慶二
School of Pharmaceutical Sciences, Kitasato University
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城谷 憲一
School of Pharmaceutical Sciences, Kitasato University
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城谷 憲一
School Of Pharmaceutical Sciences Kitasato University
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関口 慶二
School Of Pharmaceutical Sciences Kitasato University
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