Enhancement of Oral Bioavailability of D-α-Tocopherol Acetate by Lecithin-Dispersed Aqueous Preparation Containing Medium-Chain Triglycerides in Rats

概要

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In order to evalutate oral dosage forms of d-α-tocopherol acetate (VEA), d-α-tocopherol (VE) concentration in the plasma was examined following oral administration of three VEA preparations; lecithin-dispersed aqueous preparation, polysorbate 80 (PS-80)-solubiized aqueous solution and soybean oil solution. The lecithin-dispersed preparation gave the highest C_<max> and the largest AUC_<0-24h>, while T_<max> was delayed. In the thoracic duct fistula rat, no increase in VE plasma concentration was observed after intraduodenal administration of lecithin-dispersed VEA preparation, while VE appeared in the thoracic lymph, indicating that VE is absorbed from the lecithin-dispersed preparation via the lymphatic route. The delayed T_<max> and prolonged VE plasma concentration obtained with the lecitin-dispersed preparation in comparison with PS-80-solubilized aqueous solution could be explained by the different route of absorption.
公益社団法人日本薬学会の論文
1989-02-25