Studies on the Molecular Compounds of Organic Medicinals. II. Application of the Solubility Product Principle and Consideration by the Phase Rule to the Solubility Phenomena of the Molecular Compound of Sulfanilamide and Sulfathiazole
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概要
- 論文の詳細を見る
Solubilities of the molecular compound of sulfanilamide and sulfathiazole in aqueous solutions containing varying amounts of sulfanilamide were determined. It was found from the results that the solubility product principle can be applied to such mixtures. Based on the principle, a method for calculating the value of the saturated concentration of the compound was proposed. Besides, the influence of each one of the sulfonamides to solubility of the other was investigated. Using all these data, the phase diagram of the system of sulfanilamide, sulfathiazole and water was constructed which indicates that the system belongs to type where a one-to-one molecular compound is formed but is decomposed by water. It was also confirmed that the metastable solubilities of the compound observed in water and in the sulfanilamide solution can be represented by the points on the extention of the saturation curve of the molecular compound in the diagram.
- 公益社団法人日本薬学会の論文
- 1966-03-25
著者
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伊藤 圭二
Hokkaido College Of Pharmacy
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関口 慶二
Kitasato University School of Pharmaceutical Sciences
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伊藤 圭二
Faculty of Pharmaceutical Sciences, Hokkaido University
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関口 慶二
Faculty of Pharmaceutical Sciences, School of Medicine, Hokkaido University
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関口 慶二
Faculty Of Pharmaceutical Sciences School Of Medicine Hokkaido University
関連論文
- Gel Filtration of Solubilized Systems. I. On the Gel Filtration of Aqueous Sodium Lauryl Sulfate Solution Solubilizing Alkyl Paraben on Sephadex G-50
- Effects of Vegetable Oils on the Biological Disposition of Ethchlorvynol. II. The Effects on the Brain Distribution of Ethchlorvynol in Rat
- Studies on the Method of Size Reduction of Medicinal Compounds. IV. Solvate Formation of Chloramphenicol and Its Application to Size Reduction
- Thermal Analysis of Organic Medicinals. I. Detection of the Molecular Compound Formation by the Differential Thermal Analysis and by the Differential Scanning Calorimetry
- Studies on the Method of Size Reduction of Medicinal Compounds. III. Size Reduction of Griseofulvin by Solvation and Desolvation Method using Chloroform. (3)
- Studies on the Method of Thermal Analysis of Organic Medicinals. VI. Simultaneous Measurement of the Differential Temperature and of the Dielectric Behavior
- Effects of Vegetable Oils on the Biological Disposition of Ethchlorvynol. I. The Effects on the Distribution of Ethchlorvynol in Rat
- Sensitive Analytical Method for Serum Primidone and Its Active Metabolites for Single-Dose Pharmacokinetic Analysis in Human Subjects
- Correction of the Paper, Dissolution Behavior of Solid Drugs. VI. Determination of Transition Temperatures of Various Physical Forms of Sulfanilamide by Initial Dissolution Rate Measurements
- Structures of Mefenamic Acid Metabolites from Human Urine
- Effect of Acetazolamide on Barbiturate-induced Sleeping Time in Mice. II. Effect on Barbiturate Levels in the Plasma and Brain
- Effects of Macromolecular Additives and Urea on the Intestinal Absorption of Acetaminophen in Rats
- Application of the Cloud Point Method to the Study of the Interaction of Polyvinylpyrrolidone with Some Organic Compounds in Aqueous Solution
- Effect of Polymorphism on the Dissolution Behavior and Gastrointestinal Absorption of Chlortetracycline Hydrochloride
- Transformation and Excretion of Drugs in Biological Systems. IV. Reabsorption of Biliary Metoclopramide-N^4-glucuronide and -N^4-sulfonate from Rabbit Intestine
- Transformation and Excretion of Drugs in Biological Systems. III. Separatory Determination of Metoclopramide and Its N^4-Glucuronide and N^4-Sulfonate in Rabbit Urine and Bile
- Studies on the Molecular Compounds of Organic Medicinals. IV. Physico-pharmaceutical Properties of the Molecular Compound of Homosulfanilamide and Sulfathiazole
- Studies on the Method of Size Reduction of Medicinal Compounds. II. Size Reduction of Griseofulvin by Solvation and Desolvation Method using Chloroform (2)
- Transformation and Excretion of Drugs in Biological Systems. II. Transformation of Metoclopramide in Rabbits
- Dissolution Behavior of Solid Drugs. II. Determination of the Transition Temperature of Sulfathiazole Polymorphs by Measuring the Initial Dissolution Rates
- Dissolution Behavior of Solid Drugs. I. Improvement and Simplification of Dissolution Rate Measurement, and Its Application to Solubility Determinations
- Studies on the Method of Thermal Analysis of Organic Medicinals. V.^ Semi-micro Apparatus for the Differential Thermal Analysis Permitting Direct Observation.
- Studies on the Molecular Compound of Organic Medicinals.III. The Structure of the Molecular Compound of Sulfanilamide and Sulfathiazole
- Studies on the Molecular Compounds of Organic Medicinals. II. Application of the Solubility Product Principle and Consideration by the Phase Rule to the Solubility Phenomena of the Molecular Compound of Sulfanilamide and Sulfathiazole
- Studies on the Molecular Compounds of Organic Medicinals. I. Dissolution Behavior of the Molecular Compounds of Sulfanilamide and Sulfathiazole
- Studies on the Method of Thermal Analysis of Organic Medicinals. IV. Double Melting Point of Organic Binary Mixtures.
- Studies on the Method of Thermal Analysis of Organic Medicinals. III. Relations between Methods of Sample Preparation and Obtained Phase Diagrams.
- Studies on Absorption of Eutectic Mixture. II. Absorption of fused Conglomerates of Chloramphenicol and Urea in Rabbits.
- Studies on Absorption of Eutectic Mixture. I. A Comparison of the Behavior of Eutectic Mixture of Sulfathiazole and that of Ordinary Sulfathiazole in Man.
- 誘電率測定による固体医薬品中の水分定量