Polysaccharides in Fungi. XXIX. Structural Features of Two Antitumor Palysaccharides from the Fruiting Bodies of Armillariella tabescens

概要

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An antitumor polysaccharide containing peptide moieties AT-HW ([α]_D + 31° in water) and an antitumor polysaccharide AT-AL ([α]_D + 209° in 1 M sodium hydroxide) were isolated from hot-water extract and the alkaline extract of the fruiting bodies of Armillariella tabescens, respectively. Chemical structures of AT-HW and AT-AL were investigated by a combination of chemical and spectroscopic methods. The results indicate that the major constituent of AT-HW (molecular weight, 105000), a heteroglycan, is composed primarily of β-(1→6)-linked D-glucopyranosyl and D-galactopyranosyl residues, and contains their branched residues and terminal sugar (gluco-, manno-, and fucopyranose) residues, in addition to β-(1→3)-linked D-glucopyranosyl residues, while AT-AL molecular weight, 93000) is chiefly composed of α-(1→3)-linked D-glucopyranosyl residues.
社団法人日本薬学会の論文
1992-08-25