薬物の裁判化学的研究(第5報)塩化ベンザルコニウムのガスクロマトグラフィーによる分析

概要

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Benzalkonium chloride used as detergents and disinfectants was readily analyzed by gas chromatography (GC) of their reduction products obtained by their treatment with NaBH_4 and NiCl_2. The reduction products of benzalkonium chloride (alkyldimethylbenzylammonium chloride) were identified as alkyldimethylamines (I-VI) by GC-mass spectrometry. In the reduction, the benzyl groups of alkyldimethylbenzylammonium chloride was eliminated as toluene. The procedure is applicable for characterizing the distribution of long chain alkyl groups in benzalkonium chloride, and suited for the assay of 10-100 μg/ml aqueous solution of benzalkonium chloride (mainly consisting of the n-C_<12>H_<25>, n-C_<14>H_<29> and n-C_<16>H_<33> homolog components : Zephiran). Furthermore, the procedure is very useful for routine analysis of benzalkonium chloride since the reduction takes place smoothly by the use of NaBH_4 and NiCl_2 which are relatively safe to handle and inexpensive, instead of a complicated apparatus and expensive catalyst in catalytic hydrogenation.
1981-10-31