薬物の裁判化学的研究(第2報)覚せい剤混合試料中のl-エフェドリンおよびd-プソイドエフェドリンのガスクロマトグラフィーによる同時定量

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l-Ephedrine (I) and d-pseudoephedrine (II) in a mixture of sympathomimetic amines were determined simultaneously by gas chromatography of their trifluoroacetyl derivatives (I-TFA and II-TFA). Resolution of these derivatives was carried out by the gas chromatograph equipped with a hydrogen flame ionization detector in a glass column (1m×3 mm), packed with 1% SE-30 on Gas-chrom Z, at 80°, with N_2 at the flow rate of 70 ml/min. This method is well suited not only for the simultaneous determination of I and II but also for the screening test of sympathomimetic amines (phenylmethylaminopropane, phenylaminopropane, and methylephedrine). Based on the results of nuclear magnetic resonance, infrared, and mass spectra, N, O-ditrifluoroacetyl-l-ephedrine was assigned for I-TFA and N, O-ditrifluoroacetyl-d-pseudoephedrine for II-TFA.
1976-10-31