薬物の裁判化学的研究(第1報)水性除草剤中におけるDiquatならびにParaquatのガスクロマトグラフィーによる定量

概要

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A gas chromatographic method is described for determinig diquat (I) and paraquat (II), separately and simultaneously, in aqueous herbicide preparations. Analysis of I and II was performed by gas chromatography (detector : HFID) of their reduction products, which were derived by treatment with sodium borohydride. The ethyl acetate solutions of the reduction-products were injected into the gas chromatograph apparatus equipped with a glass column containing Gas-Chrom Z coated with 5% KOH and 5% PEG-6000 at 180° (usual determination) or 165° (simultaneous determination). These conditions were found to result in the satisfactory separation of the reduction products of I and II. This procedure is well suited forthe assay of 5-65 μg/ml concentration of I and II (internal standard substance : o-phenylenediamine). The main compounds isolated from the reduction-products of I and II were presumed on the basis of the results of nuclear magnetic resonance and mass spectra, and from elementary analysis to be N, N'-ethylene-1,1', 2,2', 3,3', 6,6'-octahydro-6,6'-bipyridyl (III) and N, N'-dimethyl-1,1', 2,2', 3,3', 6,6'-octahydro-4,4'-bipyridyl (IV), respectively.
公益社団法人日本薬学会の論文
1973-10-31