薬物の裁判化学的研究(第4報)水性除草剤中におけるMorphamquatのガスクロマトグラフィーによる定量

概要

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A gas chromatographic method is described for determining morphamquat (I) in aqueous herbicide preparation. The compound was analyzed by means of a gas chromatography of its reduction products obtained by treatment with sodium borohydride-nickel chloride system or with sodium borohydride alone. The reduction products were analyzed by a gas chromatography equipped with a hydrogen flame ionization detector and a 2 m×3 mm i.d. glass column packed with 1% SE-30 on Gas-chrom Z at 290° with a flow of 30 ml/min of N_2. The reduction system of NaBH_4 and NiCl_2 is well suited for the assay of 40-300 μg/ml concentration of I (internal standard : dimethyl-POPOP). The main product in NaBH_4・NiCl_2 reduction of I was presumed on the basis of the results of elemental analysis, and from infrared and mass spectra to be N, N'-bis (3,5-dimethylmorpholinecarbonylmethyl)-γ, γ'-bipiperidine (IV).
公益社団法人日本薬学会の論文
1977-04-30