Polysaccharides in Fungi. XXXII. Hypoglycemic Activity and Chemical Properties of a Polysaccharide from the Cultural Mycelium of Cordyceps sinensis
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概要
- 論文の詳細を見る
Crude polysaccharides were obtained from a hot-water extract and alkaline extracts of the cultural mycelium of Cordyceps sinensis. They showed significant activity in normal mice and streptozotocin-induced diabetic mice as a result of intraperitoneal (i.p.) injection. A crude polysaccharide (CS-OHEP) obtained from 5% sodium hydroxide extract slightly lowered the plasma glucose level in normal mice by oral (p.o.) administration. A neutral polysaccharide (CS-F30) exhibited higher hypoglycemic activity than its crude polysaccharide (CS-OHEP), exhibited by i.p. injection, and it significantly lowered the glucose level by p.o. administration (50 mg/kg). However, it hardly affected the plasma insulin level in normal mice. CS-F30 ([α]_D +21°in water) is composed of galactose, glucose and mannose (molar percent, 62 : 28 : 10), and its molecular weight is about 45000.
- 社団法人日本薬学会の論文
- 1993-12-15
著者
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木方 正
Gifu Pharmaceutical University
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鵜飼 茂夫
Gifu Pharmaceutical University
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木方 正
岐阜薬科大学
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鵜飼 茂夫
岐阜薬科大学
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李 暉
China Pharmaceutical University
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山根 章裕
Gifu Pharmaceutical University
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Kiho Tadashi
Gifu Pharmaceutical University
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