Kinetic Analysis of Malignant Fibrous Histiocytoma Cells Treated with Anticancer Agents In Vivo

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概要

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• To clarify the in vivo effects and the changes in kinetic parameters of soft tissue sarcoma caused by anticancer agents, we performed double-labeling using bromo- (BrdU) and iododeoxyuridine (IUdR). A malignant fibrous histiocytoma cell line was transplanted into nude mice, and treated with 3 anticancer agents: cisplatin, doxorubicin and vincristine. The following parameters were determined: BrdU labeling index (LI), duration of S-phase (Ts), total cell cycle time (Tc), Ki-67 labeling index (KLI), PCNA labeling index (PCNA-LI), and actual tumor volume doubling time (Tv). In addition, the apoptotic cell ratio (apoptotic index; Al) was calculated in the seria specimens using terminal deoxynucleotidyl transferase-mediated deoxyurine triphosphate nick end labeling (TUNEL). Vincristine inhibited the tumor growth the most effectively (Tv: -5.8 days). Doxorubicin suppressed the tumor growth better (Tv: 12.7 days) than cisplatin (Tv: 9.1 days). Tc values showed significant differences among the drug groups (ANOVA analysis; p<0.05), and also correlated with Tv (Pearson's analysis; R>0.7, p<0.05) on Day 1. Al peaked on Day 10 and decreased afterward in every drug group. Anticancer agents effectively suppress tumor grouwh not only by necrosis and apoptosis, but also by prolonging Tc. Tc values are possibly useful for planning chemotherapy for sarcoma patients.

• 日本組織細胞化学会の論文

著者

• Matsumoto Keiji

  Department of Mathematics, Hokkaido University

• OKABE HIDETOSHI

  Department of Clinical Pathology, Shiga University of Medical Science

• HUKUDA Sinsuke

  Department of Orthopedic surgery, Shiga University of Medical Science

• Hukuda Sinsuke

  Department Of Orthopaedic Surgery Shiga University Of Medical Science

• Okabe Hidetoshi

  Department Of Laboratory Medicine Shiga University Of Medical Science

• Okabe Hidetoshi

  Department Of Clinical Laboratory Medicine And Division Of Diagnostic Pathology

• Matsumoto K

  Osaka Univ. Ibaraki‐shi Jpn

• Matsumoto Keiji

  Department Of Orthopaedic Surgery Shiga University Of Medical Science

• Egawa Masaaki

  Department of Orthopaedic Surgery Shiga University of Medical Science

• Chano Tokuhiro

  Department of Orthopaedic Surgery Shiga University of Medical Science

• Ishizawa Michihito

  Department of Orthopaedic Surgery Shiga University of Medical Science

• Chano Tokuhiro

  Department Of Clinical Laboratory Medicine Shiga University Of Medical Science

• Matsumoto Keiji

  Department Of Applied Physics Graduate School Of Engineering Yokohama National University

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