ピロカルボン酸エステル類の抗菌性について

概要

論文の詳細を見る
Alkyl ethyl pyrocarbonates substituted with one ethyl radical of diethyl pyrocarbonate to alkyl radical (C_1〜C_5) were synthesized to find a more active combound than diethyl pyrocarbonate noticeable as an innocuous food preservative.Fungicidal action of alkyl ethyl pyrocarbonates against Candida albicans, Aspergillus niger, Rhizopus nigricans, Trichoderma viride and Trichophyton mentagrophytes were examined using Waksman's media.It was found that the activities of n-compounds increased with the increase of carbonatom's number in alkyl radical.Fungicidal actions of iso- and sec.-compounds were uncertain against each fungin. strainThe activity of tert.-butyl ethyl pyrocarbonate was higher than tert.-amyl ethyl pyrocarbonate.It was found on the whole that iso-butyl and n-amyl ethyl pyrocarbonates had the highest fungicidal activities and all alkyl ethyl pyrocarbonates examined in this report had higher fungicidal activities than diethyl pyrocarbonate with the exception of methyl ethyl pyrocarbonate.Furthermore, the effects of peptone and pH in Waksman's medium upon the activity of alkyl ethyl pyrocarbonate and its stability in the same medium were examined.
公益社団法人日本生物工学会の論文
1966-08-25