芳香族脂肪酸の化学構造と抗菌性 (第6報) : 核置換化合物についてその1

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o-Nitro-cinnamenyl acrylic acid, p-nitro-cinnamenyl acrylic acid, o-nitro-cinnamic acid, m-nitro-cinnamic acid, p-nitro-cinnamic acid, m-hydroxy-cinnamic acid and p-hydroxy-cinnamic acid were prepared and their antimicrobial activly against the yeasts (Kyokai No. 6 and Sac. formosensis), molds (Asp. awamori and Rh. japonicus) and bacteria (Bac. subtilis and Lact. delbrucki) were examined.The resuts obtained are summarized as follows : - 1) Both o-nitro-cinnamenyl acrylic acid and p-nitro-cinnamenyl acrylic acid had remarkable inhibitory power against the bacteria, but their power against the yeasts and molds was weak.2) The inhibitory effect of o-nitro-cinnamic acid, m-nitro-cinnamic acid, p-nitro-cinnamic acid, m-hydroxy-cinnamic acid and p-hydroxy-cinnamic acid on the micro-organisms closely resembled that mentioned in (1).3) The inhibitory power of nitro-compounds mentioned above increased with the mobility of the NO_2-group.4) The inhibitory power of m-hydroxy-cinnamic acid against the micro-organisms was not remarkably different from that of p-hydroxy-cinnamic acid, but the former seemed to be a little stronger.
公益社団法人日本生物工学会の論文
1960-07-15