チアミン欠乏ラット及びニコチンアミド大量負荷チアミン欠乏ラットのトリプトファン-NAD代謝

概要

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Male rats of Sprague Dawley strain (5-week old) were divided into four groups and then fed thiamin-free, thiamin-free + 1% nicotinamide, normal (thiamin-free diet+0.59 mg%thiamin hydrochloride) and the normal + 1% nicotinamide diets for 24-29 days. Tryptophan metabolites in the liver, blood and urine, thiamin in the liver and urine and enzyme activities of tryptophan-NAD pathway and of transketolase were compared among the four groups. NAD level in the blood and liver was almost the same between the normal and the thiamin-free groups, while that in the group of the normal+nicotinamide diet was much higher than that in the group of the thiamin-free+nicotinamide diet. The activity of liver nicotinamide methyltransferase and amount of N^1- methylnicotinamide in both thiamin-free groups were significantly increased in comparison with those in both normal groups. Urinary thiamin excretion was significantly higher in the thiamin-free+nicotinamide group than in the thiamin-free group. The same relation of thiamin excretion was also observed between the groups of the normal and normal+nicotinamide.
日本ビタミン学会の論文
1985-11-25