飼料中の油脂含量がN^1-メチルニコチンアミドとその酸化体との排泄量比に及ぼす影響

概要

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Effect of dietary corn oil content on the urinary excretion ratio of (N^-methyl-2-pyridone-5^carboxamide + N^1-methyl-4-pyridone-3-carboxamide)/N^1-methylnicotinamide was investigated using rats. The male rats of the Wistar strain (3 weeks old) were fed on a 20% casein -0% corn oil, 20% casein - 5% corn oil (control) or 20% casein - 20% corn oil diet ad libitum for 41 days and the rats were then killed by decapitation. Urine samples were collected periodically. The excretion ratio was always statistically significantly higher in the 5% corn oil group than in the 0% and 20% corn oil groups and the liver N^1-methyl-4-pyridone-3-carboxamide-forming N^1-methylnicotinamide oxidase activity, which affects the excretion ratio, was statistically significantly higher in the 5% oil group than in the 0% and 20% oil groups. Accordingly, it was found that low of high dietary oil content lowers the excretion ratio of N^1-methyl-2-pyridone-5-carboxamide + N^1-methyl-4-pyridone-3-carboxamide)/ N^1-methylnicotinamide.
日本ビタミン学会の論文
1991-06-25