Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines
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概要
- 論文の詳細を見る
2-(Substituted benzylamino)-2-thiazolines (SBAT) were synthesized by a hydrochloric acid-catalyzed cyclization of the corresponding thioureas, using a reaction of 2-methylthio-2-thiazoline with substituted benzylamines or by alkylating 2-amino-2-thiazoline. 2-(Alkylthio)-2-thiazolines were obtained by alkylating 2-mercaptothiazoline. Most of the SBAT compounds activated adenylate cyclase in homogenates of cockroach ventral nerve cords ; the effect of introducing substituents at the phenyl of the SBAT compounds on octopaminergic agonist activity was not significant. 2-[β-(Substituted phenyl)ethylamino]-2-thiazolines and 2-(alkylthio)-2-thiazolines were not significant octopaminergic agonists. Washing removed nearly all of the activity of one of the SBAT compounds, suggesting that the SBAT compounds bound reversibly to the octopaminergic receptor.
- 社団法人日本農芸化学会の論文
- 1992-07-23
著者
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ETO Morifusa
Department of Agricultural Chemistry, Kyushu University
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HIRASHIMA Akinori
Department of Agricultural Chemistry, Kyushu University
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Yoshii Yutaka
High Frequency & Optical Semi-conductor Division Mitsubishi Electric Corporation
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Yoshii Yutaka
Department Of Agricultural Chemistry Kyushu University
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Hirashima A
Department Of Applied Genetics And Pest Management Faculty Of Agriculture Graduate School Kyushu Uni
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Hirashima Akinori
Department Of Agricultural Chemistry Kyushu University
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Eto Morifusa
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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