Stereochemistry of Aryl Methyl Phosphorochloridothionates as Chiral Two-step Phosphorylating Reagents
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概要
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Seven aryl methyl phosphorochloridothionates were prepared and examined for reactivity as two-step phosphorylating reagents to synthesize oxazaphospholidine sulfide. The 2, 6-dichloro-4-methylphenyl and p-nitrophenyl derivatives (CMPC and MNPC) were selected and resolved into optically active enantiomers. Their absolute configurations were determined. Even in the presence of an alcohol, an amine first attacked the phosphorus displacing the chloride ion. The amide that was produced reacted with an alkoxide to displace the aryloxide ion. Both the substitutions underwent inversion of the configuration.
- 社団法人 日本農芸化学会の論文
著者
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Wu Shao-yong
Department Of Agricultural Chemistry Kyusyu University
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Eto Morifusa
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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