Reaction of Toxic Bicyclic Phosphates with Acetylcholinesterases and α-Chymotrypsin
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概要
- 論文の詳細を見る
Some toxic bicyclic phosphates. (BPs) inhibited acetylcholinesterases (AChEs), but the activity was very weak. Even the most potent inhibitor, 4-nitro BP, inhibited bovine erythrocyte and housefly head AChEs by only 37 and 38 per cent, respectively, at 1.5 HIM. Kinetic analysis indicated that the poor inhibitory activity of 4-nitro BP is ascribed not only to the low affinity for AChEs but also to its poor phosphorylating ability. Similar findings were obtained in the case of the reaction of BPs with the serine enzyme α-chymotrypsin. Despite the relatively high reactivity in an alkaline solution, BPs are much less active than other bioactive organophosphorus esters in phosphorylating a general-base-catalyzed hydroxyl group. This fact suggests that the toxic action of BPs does not result from the phosphorylation of a critical site in biological systems.
- 社団法人 日本農芸化学会の論文
著者
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Eto Morifusa
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Mochida Kazuo
Department of Agricultural Chemistry, Shimane University
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OZOE Yoshihisa
Department of Agricultural Chemistry, Kyushu University
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