Synthesis of Highly Pure Enantiomers of the Insecticide Salithion
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概要
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Optically active salithion (>98% e.e.) was obtained via an L-proline methyl ester derivative (PS), whose diastereomers were easily separated, with subsequent sulfuric acid-catalyzed methanolysis. The configuration of each diastereomeric PS was determined by NMR and single-crystal X-ray analysis. *The optical purity of each PS and of the salithion enantiomers was measured by 1H-NMR and HPLC, respectively. The sulfuric acid-catalyzed methanolysis of PS to salithion was confirmed to have proceeded with an inversion of the configuration at the phosphorus atom by an experiment using model compounds.
- 社団法人 日本農芸化学会の論文
著者
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Moriguchi Koichi
Takatsuki Research Laboratory Sumitomo Chemical Co. Ltd.
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Wu Shao-yong
Department Of Agricultural Chemistry Kyusyu University
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Yanagi Kazunori
Takatsuki Research Laboratory Sumitomo Chemical Co. Ltd.
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Hirashima Akinori
Department Of Agricultural Chemistry Kyushu University
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Eto Morifusa
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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NISHIOKA Eriko
Takatsuki Research Laboratory, Sumitomo Chemical Co., Ltd.
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