Effects of a Muscarinic Agonist on Octopamine-stimulated Cyclic AMP Production in American Cockroach (Periplaneta americana) Nerve Cords(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
In the presence of 0.5 mM EGTA (a calcium chelator), the muscarinic agonist carbachol at 0.1 mM inhibited octopamine-stimulated cyclic AMP (cAMP) production in intact ventral nerve cords of Periplaneta americana. This effect was reduced by the addition of 0.1 mM atropine (a muscarinic antagonist), suggesting that the effect is mediated via muscarinic acetylcholine receptors (mAChR). This inhibitory effect of carbachol was not observed in the synaptosomes of nerve cords, suggesting that the inhibitory effect was not due to direct coupling of the mAChR to adenylate cyclase but mediated by other second messengers. The inhibitory effect seems to be due to an increase in the intracellular calcium level. In the presence of exogeneous extracellular 0.25 mM Ca^<2+> the octopamine-stimulated cAMP production was lower than that in the absence of extracellular Ca^<2+>, and the cAMP levels were not further reduced by adding carbachol to the octopamine-stimulated cAMP production system. Washing did not remove all of the inhibitory activity of carbachol in intact nerve cords, indicating that carbachol modulated octopaminergic neurotransmission irreversibly.
- 社団法人日本農芸化学会の論文
- 1991-10-23
著者
-
ETO Morifusa
Department of Agricultural Chemistry, Kyushu University
-
HIRASHIMA Akinori
Department of Agricultural Chemistry, Kyushu University
-
OYAMA Kazuhiko
Department of Agricultural Chemistry, Kyushu University
-
Eto Morifusa
Department Of Agricultural Chemistry Kyushu University
-
Oyama Kazuhiko
Department Of Agricultural Chemistry Kyushu University:(present Office)pharmaceutical Research Labor
-
Hirashima A
Department Of Applied Genetics And Pest Management Faculty Of Agriculture Graduate School Kyushu Uni
-
Hirashima Akinori
Department Of Agricultural Chemistry Kyushu University
-
Eto Morifusa
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
関連論文
- Effects of Some Anti-Juvenile Hormone Agents (Precocene-2, J-2710, KK-110) on Postembryonic Development of Neobellieria bullata(Pesticide Chemistry)
- Effect of Salithion Enantiomers on Larval Growth, Carbohydrases, Acetylcholinesterase, Adenylate Cyclase Activities and Cyclic Adenosine 3',5'-monophosphate Level of Musca domestica and Tribolium castaneum(Pesticide Chemistry)
- B309 フェロモン分泌阻害剤の pharmacophore モデリング
- Synthesis and Octopaminergic Agonist Activity of 2-(Substituted benzylamino)-2-thiazolines
- Synthesis and Biological Activity of 2-Aminothiazolines and 2-Mercaptothiazolines as Octopaminergic Agonists(Pesticide Chemistry)
- Root Growth-promoting Activities of N-Acyl-L-proline Derivatives
- Metabolic Formation of 4-Methy-4H-1, 3, 2-benzodioxaphosphorins from Bis(o-ethylphenyl) Phenylphosphonates in House Flies(Pesticide Chemistry)
- Studies on the Mechanisms of Organophosphate Resistance in Oriental Houseflies, Musca domestica vicina MACQUART. (Diptera : Muscidae)
- Carbohydrate Enzymes in House Fly Musca domestica Larvae : Biochemical Properties and Toxicological Significance
- Potency of Isomers of 8-Isopropyl-6-oxabicyclo[3.2.1]octan-7-one at the Picrotoxinin Binding Site in the GABA-Gated Chloride Channel in Rat Brain
- Threshold Size for Precocious Metamorphosis by an Anti-Juvenile Hormone in Silkworm Larvae, Bombyx mori L.
- Precocious Metamorphosis Induced by an Anti-Juvenile Hormone Compound Applied to 3rd Instar Silkworm Larvae, Bombyx mori L. (Lepidoptera : Bombycidae)
- Anti-Juvenile Hormone Activity of Imidazole Compound (KK-22) and Its Diminution by Methoprene in the 4th Instar Silkworm, Bombyx mori L. : Lepidoptera : Bombycidae
- Anti-Juvenile Hormone Activity of 1-Citronellyl-5-phenylimidazole in the 3rd Instar Silkworm, Bombyx mori L.(Lepidoptera : Bombycidae)
- Synthesis and Insecticidal Activity of Bicyclic Phosphorothionates and Related Monocyclic Phosphorothionates
- Synthesis and Insecticidal Activity of Oxazaphospholidines, Oxathiaphospholanes, and Thiazaphospholidines(Pesticide Chemistry)
- Synthesis of Optically Active 1,3,2-Oxazaphospholidine 2-Sulfides and 1,3,2-Benzodioxaphosphorin 2-Sulfides(Organic Chemistry)
- Regulation of bombykol production by tyramine and octopamine in Bombyx mori
- Synthesis and Octopaminergic-agonist Activity of 3-(Substituted Phenyl) imidazolidine-2-thiones and Related Compounds
- Effects of a Muscarinic Agonist on Octopamine-stimulated Cyclic AMP Production in American Cockroach (Periplaneta americana) Nerve Cords(Biological Chemistry)
- Synthesis and Bleaching Activity of 1,5-Disubstituted Imidazoles
- Chemical Reactivity of Oxidation Products of the Dithiolanylidenemalonate Fungicide, Isoprothiolane
- Stress-induced Changes in the Biogenic Amine Levels and Larval Growth of Tribolium castaneum Herbst
- Anti-Ecdysteroid Action of Some Imidazole Derivatives on Pupal-Adult Development of the Silkworm, Bombyx mori : Lepidoptera : Bombycidae
- Effects of Methoprene and 20-Hydroxyecdysone on the Precocious Metamorphosis Induced by 1,5-Disubstituted Imidazoles
- Syntheses and Biological Activities of Some Dithiolanylidenemalonate Derivatives and Related Compounds
- Chlorosis-inducing Activity of 1-Alkyl-5-phenylimidazoles
- Synthesis and Insect Growth Regulatory Activity of 1,5-Disubstituted Imidazoles with Non-terpene Chains(Pesticide Chemistry)
- Effects of 1,5-Disubstituted Imidazoles on the Growth of Lettuce and Rice Seedlings
- Synthesis and Plant Growth Regulatory Activity of 1,5-Disubstituted Imidazoles
- Lethal Disturbances in the Pre-ecdysial Processes of Sarcophaga bullata Caused by Imidazole Containing KK-42(Pesticide Chemistry)
- Effects of Anti Juvenile Hormones and Related Compounds on Development in the Larvae of Bombyx mori
- Induction of Precocious Metamorphosis by 1,5-Disubstituted Imidazoles with a Non-terpene Chain(Pesticide Chemistry)
- Characteristics of Houseflies Selected by Fenitrothion and Diethyl Fenitrothion (Pesticide Chemistry)
- Termination of Egg Diapause by Imidazoles in the Silkmoth, Antheraea yamamai(Pesticide Chemistry)
- Synthesis of Two Optical Isomers of the Insect Anti-juvenile Hormone Agent Fluoromevalonolactone (FMev) and Their Biological Activities(Organic Chemistry)
- Anti-juvenile Hormone Effects of an Imidazole Compound (KK-42) in Different Larval Instars of Bombyx mori
- Ethanolysis of Substituted 2-Ethoxy-1,3,2-oxazaphospholidine and -thiazaphospholidine Oxides Monitored by ^P-NMR as a Model for Interaction with Acetylcholinesterase
- Synthesis and Octopaminergic-agonist Activity of 2-(Arylimino)thiazolidines, 2-(Aralkylamino)-2-thiazolines, and Related Compounds
- Ecdysteroids in Stress Responsive and Nonresponsive Drosophila Virilis Lines under Stress Conditions
- Biogenic Amines in Drosophila virilis under Stress Conditions
- Biogenic Amines in Periplaneta americana L.: Accumulation of Octopamine, Synephrine, and Tyramine by Stress
- Binding of Toxic Bicyclic Phosphates to Rat Brain Synaptic Membrane Fractions
- Synthesis of Highly Pure Enantiomers of the Insecticide Salithion
- An Imidazole Compound as a Potent Anti-ecdysteroid in an Insect
- Terpenoid Imidazoles : New Anti-juvenile Hormones
- Insecticidal Benzimidazoles with a Terpenoid Moiety
- Effects of Insect-Growth-Regulatory Benzimidazole Derivatives on Cultured Integument of the Rice Stem Borer and Mitochondria from Rat Liver
- Molecular Structure and Conformation of 4H-l, 3, 2-Benzodioxaphosphorins, Including the Insecticide Salithion
- Synthesis and And-Juvenile Hormone Activity of 1-Substituted-5-[(E)-2, 6-dimethyl-1, 5-heptadienyl]imidazoles
- The Use of a Tribalium Chitin Synthetase Assay in Studying the Effects of Benzimidazoles with a Terpene Moiety and Related Compounds
- Synthesis and Anti-juvenile Hormone Activity of 1-Citronellyl-5-substituted Imidazoles
- Biological Activity of Optically Active Salithion and Salioxon
- Synthesis and Insecticidal Activity of Optically Active 2-Methoxy-5-phenyl-1, 3, 2-oxazaphospholidine 2-Sulfide
- Studies on Insect Growth Regulating Substances with Insect Cell Cultures
- Synthesis and Some Spectral Characteristics of Bicyclic Phosphate, GABA Antagonists
- Synthesis and Biological Activity of 0, 0-Dialkyl S-(5-Aryl-1, 3, 4-oxadiazol-2(3H)-on-3-yl)methyl Phosphorothioates and Phosphorodithioates
- Stereochemistry and Reactions of Aziridinylphosphinothionates Derived from Amino Acids
- Reaction of Toxic Bicyclic Phosphates with Acetylcholinesterases and α-Chymotrypsin
- Bicyclic Phosphate Binding to Cyclodextrin: A Receptor Model
- Stereochemistry of Aryl Methyl Phosphorochloridothionates as Chiral Two-step Phosphorylating Reagents
- Glutathione-dependent Degradation of Organophosphate Insecticides by Organophosphate-susceptible and Resistant Housefly Abdomen Homogenates