3-Geranyl-4-hydroxy-5-(3'-methyl-2'-butenyl) benzoic Acid as an Anti-inflammatory Compound from Myrsine seguinii
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概要
- 論文の詳細を見る
Bioassay-guided isolation of anti-inflammatory compounds from the methanol extract of Myrsine seguinii yielded an anti-inflammatory compound (1). The structure of compound 1 was elucidated to be 3-geranyl-4-hydroxy-5-(3'-methyl-2'-butenyl) benzoic acid on the basis of its spectroscopic data. Compound 1 strongly suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation on mouse ears at a dose of 500 μg (inhibitory effect (IE) : 65%). The acetate and the methyl ether of 1 showed moderate activity at a 500-μg application, with IE 38% and 27%, respectively. However, the methyl ester and the dimethyl derivative of 1 did not show activity at the same dose. The related compounds of 1,o-, m- and p-hydroxybenzoic acids also did not exhibit notable activity. These results indicate that the carboxylic acid and lipophilic terpene moieties of 1 were significant structural features for anti-inflammatory activity.
- 社団法人日本農芸化学会の論文
- 1999-09-23
著者
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Dong M
Gifu Univ. Gifu Jpn
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Hirota Mitsuru
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Iriye Ryozo
Department Of Agricultural Chemistry Faculty Of Agriculture University Of Mie
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MIYAZAKI Shintaro
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University
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Miyazaki Shintaro
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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DONG Mei
The United Graduate School of Agricultural Science, Gifu University
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NAGAOKA Maki
Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University
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Nagaoka Maki
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Dong Mei
The United Graduate School Of Agricultural Science Gifu University
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IRIYE Ryozo
Department of Agricaltural Chemistry, Faculty of Agriculture, Shinshu University
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