(10E, 12Z, 15Z)-9-Hydroxy-10,12,15-octadecatrienoic Acid Methyl Ester as an Anti-inflammatory Compound from Ehretia dicksonii

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概要

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• The methanol extract of Ehretia dicksonii provided (10E, 12Z, 15Z)-9-hydroxy-10,12,15-octadecatrienoic acid methyl ester (1) which was isolated as an anti-inflammatory compound. Compound 1 suppressed 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced inflammation on mouse ears at a dose of 500 μg (the inhibitory effect (IE) was 43%). Linolenic acid methyl ester did not inhibit this inflammation at the same dose. However, the related compounds of 1,(9Z, 11E)-13-hydroxy-9,11-octadecadienoic acid (5) and (9Z, 11E)-13-oxo-9,11-octadecadienoic acid (6), showed potent activity (IE_<500μg> of 63% and 79%, respectively). Compounds 1,4 ((9Z, 12Z, 14E)-16-hydroxy-9,12,14-octadecatrienoic acid), 5 and 6 also showed inhibitory activity toward soybean lipoxygenase at a concentration of 10 μg/ml.

• 社団法人日本農芸化学会の論文
• 2000-04-23

著者

• Hirota Mitsuru

  Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University

• DONG Mei

  The United Graduate School of Agricultural Science, Gifu University

• ODA Yukiko

  Department of Bioscience and Biotechnology, Faculty of Agriculture, Shinshu University

• Dong Mei

  The United Graduate School Of Agricultural Science Gifu University

• Oda Y

  Osaka Univ. Osaka Jpn

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