Arginine Enhances Induction of T Helper 1 and T Helper 2 Cytokine Synthesis by Peyer's Patch αβ T Cells and Antigen-Specific Mucosal Immune Response
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概要
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The effects of arginine on cell proliferation and subsequent T helper (Th) 1 and Th 2 cytokine synthesis by murine Peyer's patch (PP) Th cells in vitro and the influence of arginine on the induction of antigen-specific mucosal and systemic immune responses in vivo were examined. When the PP T cells were stimulated with the anti-αβ T cell receptor (TCR) antibody in the presence of different concentrations of arginine, a higher proliferative response was observed in the culture with an optimal concentration of arginine compared with that with a minimum amount of this amino acid. The concentration of cytokines in the supernatant, the number of cytokine-producing cells and the cytokine-specific mRNA expression of PP T cells were also increased in a dose-dependent fashion. Furthermore, when mice fed on an arginine-supplemented liquid diet were orally immunized with tetanus toxoid plus cholera toxin as a mucosal adjuvant, a higher level of antigen-specific fecal IgA was observed when compared with the response in mice fed on an arginine-free diet. Taken together, these results suggest that arginine enhanced antigen-specific mucosal immune response resulting from the supporting activation of cell proliferation and subsequent cytokine synthesis of PP Th cells.
- 社団法人日本農芸化学会の論文
- 1998-12-23
著者
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Yamamoto Masafumi
Department of Oral Medicine, Research Institute of Oral Science, Nihon University School of Dentistr
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Yamamoto M
Ntt Electronics Corporation
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Yamamoto M
Nihon University Graduate School Of Dentistry At Matsudo Clinical Pathology:department Of Oral Medic
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Mcghee Jerry
Departments Of Oral Biology And Microbiology Immunobiology Vaccine Center The University Of Alabama
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Mcghee Jerry
Department Of Microbiology And Oral Biology Immunobiology Vaccine Center University Of Alabama At Bi
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KOBAYASHI Toshiya
Department of Cardiovascular Surgery, Toranomon Hospital
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Yamamoto Mitsuo
Ntt Electronics Corporation
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HIROI Takachika
Department of Allergy and Immunology, Tokyo Metropolitan Institute of Medical Science
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Yamamoto Masafumi
Department Of Materials Science Faculty Of Engineering Chiba University
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TAKESHITA Yasuyoshi
Life Science Research Institute, Snow Brand Milk Products Co. Ltd.
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KIYONO Hiroshi
Departments of Oral Biology and Microbiology, Immunobiology Vaccine Center, The University of Alabam
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Yamamoto M
Nihon Univ. School Of Dentistry At Matsudo Chiba Jpn
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Kiyono H
Univ. Alabama At Birmingham Al Usa
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Kiyono Hiroshi
Department Of Mucosal Immunology The Institute Of Medical Science The University Of Tokyo
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Kobayashi Toshiya
Department Of Agricultural Chemistry The University Of Tokyo
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Kobayashi Toshiya
Departments Of Oral Biology And Microbiology Immunobiology Vaccine Center The University Of Alabama
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Yuda M
Yonago National Coll. Technol. Tottori
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Hiroi Takachika
Department Of Mucosal Immunology Research Institute For Microbial Diseases Osaka University
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Hiroi Takachika
Department Of Allergy And Immunology Tokyo Metropolitan Institute Of Medical Science
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Takeshita Y
Snow Brand Milk Products Co. Ltd. Tochigi Jpn
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Yamamoto Masafumi
Department Of Computer Science And Engineering Nagoya Institute Of Technology
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YAMAMOTO Masafumi
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University
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