Enterotoxin Adjuvant for mucosal immunity
スポンサーリンク
概要
- 論文の詳細を見る
The basic structure and biological function of cholera toxin (CT) and heat-labile toxin of enterotoxigenic Escherichia coli (LT), which induces diarrhea in humans, are similar. Both CT and LT act as adjuvants for the enhancement of mucosal and serum antibody responses to the mucosally co-administered protein antigen. CT acts as an adjuvant by inducing IL-4-dependent Th2 cytokine responses, which provide help for antigen-specific secretory IgA (S-IgA) as well as serum IgG1, IgA and IgE antibody responses. On the other hand, LT induces Th1- and partly IL-4-independent Th2-type cells with subsequent serum IgGl, IgG2a and mucosal S-IgA responses. Nontoxic mutant CT (mCT) and the chimeric molecule that combine the A subunit of mCT with the B subunit of LT (mCTA/LTB), like nCT, act as mucosal adjuvants and induce mucosal IgA and systemic IgG and IgA antibody responses. These studies indicate that ADP-ribosyltransferase activity can be separated from the adjuvant properties of CT and LT. Further, those nontoxic enterotoxin derivatives should be considered as candidate mucosal adjuvants for vaccinating humans.
- 日本大学の論文
著者
-
Kiyono Hiroshi
Division Of Mucosal Immunology Department Of Microbiology And Immunology The Institute Of Medical Sc
-
Kiyono Hiroshi
Division Of Mucosal Immunology Department Of Microbiology And Immunology The Institute Of Medical Sc
-
Yamamoto Masafumi
Department Of Oral Medicine Nihon University School Of Dentistry At Matsudo
-
Yamamoto Masafumi
Department Of Computer Science And Engineering Nagoya Institute Of Technology
-
YAMAMOTO Masafumi
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University
関連論文
- Frontier Molecular Orbital Study for the Reaction of Tresyl Chloride
- Modeling and Compensation for Angular Transmission Error in Harmonic Drive Gearings
- T Helper Cytokine Responses Elicited by Nasal Immunization with Heat-Killed Recombinant Lactobacillus casei Expressing Outer Membrane Protein of Porphyromonas gingivalis
- Immunogenicity and Protective Efficacy of Heat-Killed Recombinant Lactobacillus casei Expressing Outer Membrane Protein of Porphyromonas gingivalis
- Nasal Vaccination with an Outer Membrane Protein of Porphyromonas gingivalis and Nontoxic Chimeric Enterotoxin Adjuvant Induces Both T Helper 1 and T Helper 2 Responses
- Nasal immunization with a 40-kDa Outer Membrane Protein of Porphyromonas gingivalis Inhibits Atherosclerotic Plaque Accumulation Caused by Oral P. gingivalis Infection
- Role of Gut-Associated Lymphoreticular Tissues in Intestinal IgA Immunity(Infection and Immunity)
- In vitro Study of Collagen Coating of Titanium Implants for Initial Cell Attachment
- CpG Oligodeoxynucleotide is an Effective Adjuvant for Transcutaneous Immunization
- Thermal Expansion of a 60mol% para-Hydroxybenzoic Acid/40mol% Ethylene Terephthalate Liquid Crystalline Copolyester Oriented in a Magnetic Field
- Arginine Enhances Induction of T Helper 1 and T Helper 2 Cytokine Synthesis by Peyer's Patch αβ T Cells and Antigen-Specific Mucosal Immune Response
- A Fusion Protein of the Hemagglutinin A Antigenic Region of Porphyromonas gingivalis and Maltose-Binding Protein Induces Antibody Responses in the Oral Cavity
- T Helper Cytokine Responses Induced by Nasal Immunization with Glucosyltransferase-I of Streptococcus sobrinus
- Nasal Immunization with P. gingivalis Surface Protein Antigen and Cholera Toxin Adjuvant Induces T Helper 2 Responses in Both Mucosal and Systemic Compartments
- Mucosal Immunity in CD4-Deficient Mice : Direct Evidence for Mucosal IgA Antibody Responses
- Aggregatibacter actinomycetemcomitans Leads to Endothelial Apoptosis and Atherosclerosis Development in Spontaneously Hyperlipidemic Mice
- Tonic B cell activation by Radioprotective105/MD-1 promotes disease progression in MRL/Ipr mice
- Superconductivity in One-Dimensional TaSe_3
- Role of interleukin-15 in the development of mouse olfactory nerve
- I THE MUCOSAL IMMUNE SYSTEM FOR THE DEVELOPMENT OF NEW GENERATION VACCINE
- Enterotoxin Adjuvant for mucosal immunity
- Superconducting Transition Temperature and Magnetic Susceptibility in the Solid Solution Nb_Mo_xSe_2 and Nb_Ti_ySe_2
- Role of γδ T cells in mucosal intranet
- Introduction to Mucosally-Induced Tolerance : from Bench to Bedside
- Intranasal Immunization with Porphyromonas gingivalis Outer Membrane Protein Inhibits P. gingivalis-induced Atherosclerosis in C57BL/6 Mice Fed a Hgh-fat Diet
- Glucosyltransferase-I is Capable of Functioning as an Adjuvant to Promote Immune Responses Against the Co-administered Protein Glucosyltransferase-B
- Nasal Vaccination with a Fusion Protein of Hemagglutinin A Antigenic Region and Maltose-Binding Protein Elicits CD4+ T Cell Responses via Toll-Like Receptor 4
- Correlation between the Amount of Glucosyltransferase-B and the Decayed, Missing and Filled Teeth Index in Oral Samples
- Postnatal Lymphotoxin-.ALPHA.-Mediated Signals Reorganize Splenic Microarchitecture
- Nasal immunization with the 40-kDa outer membrane protein of Porphyromonas gingivalis plus cholera toxin induces protective immunity in aged mice
- Serum Antibodies against Porphyromonas gingivalis GroEL are Insufficient to Induce P.gingivalis-accelerated Atherosclerosis
- Characterization of Inflammation-derived CD11c+ Dendritic Cells in Mouse Model of Periodontal Disease
- Functional Imbalance between Th17, Th1, and Treg Cells in A. actinomyctemcomitans -Accelerated Atherosclerosis
- Transcutaneous Immunization Induces a Higher Antibody Immune Response than Parenteral Immunization
- Superconducting Properties of TaSe_3