Transcutaneous Immunization Induces a Higher Antibody Immune Response than Parenteral Immunization
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概要
- 論文の詳細を見る
Transcutaneous immunization is a novel strategy of vaccination that utilizes a topical application of antigen to intact skin for induction of immune responses. In this study, we have assessed the potential for application of transcutaneous immunization for development of novel vaccine delivery system. When BALB/c mice were immunized with ovalbumin (OVA) by direct application to shaved skin, OVA-specific serum IgG as well as IgA antibody responses were induced. Interestingly, OVA-specific serum IgG responses were higher than those induced by the intraperitonial immunization. Antigen-specific cell proliferative responses confirmed the antibody titers and showed that significantly higher levels of OVA-specific proliferative responses were induced in the CD4+ T cells from spleen of mice transcutaneously immunized with OVA when compared with levels induced in CD4+ T cells from mice given OVA intraperitonially. Interestingly, while OVA-specific T helper cells from mice immunized intraperitonially produced high IFN-γ with low IL-4 when restimulated with OVA in vitro, transcutaneous immunization resulted in the induction of low IFN-γ with high IL-4 responses. Finally, transcutaneous, but not intraperitonial, immunization with OVA elicited OVA-specific mucosal IgA antibodies in the intestinal tract. These results indicate that transcutaneous immunization may be a better antigen delivery route for induction of antigen-specific antibody responses than parenteral immunization.
- 日本大学松戸歯学部 口腔科学研究所の論文
著者
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Kurita-Ochiai Tomoko
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo
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YAMAMOTO Masafumi
Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Chiba University
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Hashizume Tomomi
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo
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Ishikura Kazuaki
Nihon University Graduate School of Dentistry at Matsudo, Clinical Pathology
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Makimura Masaharu
Nihon University Graduate School of Dentistry at Matsudo, Clinical Pathology
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