A New Nucleophilic Ring Opening of an Activated Cyclopropane and a Formal Synthesis of (±)-Carbovir

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概要

• 論文の詳細を見る

• The reaction of bicyclo[3.1.0]hexane 1, possessing a doubly activated cyclopropane ring, with acetic acid and potassium acetate in DMSO proceeded smoothly to give the adduct 2 in good yield. A formal total synthesis of the potent anti-HIV agent (±)-carbovir (9) was done by converting 2 into a known precursor 8 in 8 steps via allyl alcohol 7 including the regioselective introduction of a double bond (4 to 5) and attachment of the nucleobase using the Mitsunobu reaction (7 to 8).

• 社団法人日本農芸化学会の論文
• 1995-11-23

著者

• NAKAYAMA Mitsuru

  Department of Agricultural Chemistry, University of Osaka Prefecture

• Tanimori Shinji

  Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture

• Nakayama M

  Juntendo Univ. School Of Medicine Tokyo Jpn

• Tsubota Masakazu

  Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University

• He Mingqi

  Department of Applied Biochemistry, College of Agriculture, Osaka Prefecture University

• Tanimori S

  Department Of Applied Biological Chemistry Graduate School Of Agriculture And Life Sciences Osaka Pr

• He M

  Zhongshan Univ. Guangzhou Chn

• Tanimori Shinji

  Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture

• Nakayama Mitsuru

  Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture

• Tsubota Masakazu

  Department Of Applied Biochemistry College Of Agriculture Osaka Prefecture University

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