Chromosomal Instability in Acute Myelocytic Leukemia and Myelodysplastic Syndrome Patients among Atomic Bomb Survivors
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概要
- 論文の詳細を見る
To clarify the mechanism of leukemogenesis in atomic bomb survivors, leukemic cells were investigated using fluorescence in situ hybridization (FISH) analysis on the basis of conventional G-banding in patients with a history of radiation exposure and also in de novo patients. Conventional G-banding showed higher incidences (p < 0.005) of structural and numerical abnormalities without any specific types of chromosome aberrations in the group exposed to a dose of more than one Gy, compared to the non-exposed group. FISH analysis revealed significantly higher incidences (P < 0.05) of subclones with monosomy 7 and deletion of the 20q13.2 region, which were not found in conventional cytogenetic analysis in the exposed group (more than one Gy) compared to the non-exposed controls. Furthermore, segmental jumping translocation (SJT) of the c-MYC gene region was observed only in the exposed group. These chromosomal instability suggested that the leukemic cells from the heavily exposed patients contained persistent cellular genetic instability which may strongly influence the development of leukemia in people exposed to radiation.
- 日本放射線影響学会の論文
著者
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Tanaka Kimio
Department Of Physics School Of Medicine Sapporo Medical University
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KAMADA NANAO
Department of Cancer Cytogenetics
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Shintani Takahiro
Department Of Second Pathology Hiroshima University School Of Medicine
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Kamada N
Department Of Cancer Cytogenetics Research Institute For Radiation Biology And Medicine Hiroshima Un
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Tanaka Kimio
Department Of Biology Faculty Of Science Konan University
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Shintani Takahiro
Department Of Cancer Cytogenetics Division Of Molecular Biology Research Institute For Radiation Bio
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Kamada Nanao
Department Of Cancer Cytogenetics Division Of Molecular Biology Research Institute For Radiation Bio
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NAKANISHI MITSUE
Department of Cancer Cytogenetics, Division of Molecular Biology, Research Institute for Radiation B
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TAKAHASHI TOMOKO
Department of Cancer Cytogenetics, Division of Molecular Biology, Research Institute for Radiation B
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Nakanishi Mitsue
Department Of Cancer Cytogenetics Division Of Molecular Biology Research Institute For Radiation Bio
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Shintani Takahiro
Department Of Bioindustrial Informatics And Genomics Graduate School Of Agricultural Science Tohoku
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Tanaka Kimio
Department Of Cancer Cytogenetics Division Of Molecular Biology Research Institute For Radiation Bio
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Takahashi Tomoko
Department Of Cancer Cytogenetics Division Of Molecular Biology Research Institute For Radiation Bio
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