Comet Assay to Assess the Non-target Effect of Neutronradiation in Human Peripheral Blood
スポンサーリンク
概要
- 論文の詳細を見る
The non-target effect of neutron-irradiation was assessed in unirradiated human peripheral blood lymphocytes using an alkaline comet assay. The isolated cells were incubated with an autologous plasma for 1 h at 37℃ before performing the assay. The cells exhibited a significant increase in the tailmoment when the irradiated blood (2 Gy, 570 keV neutron) was the source of plasma. The genotoxic effect lasted for 96 h when stored at .20℃. It is believed to be mediated by the release of cytokines or other factors released by the irradiated cells. Plasma obtained from unirradiated blood or further irradiation of plasma did not enhance the tailmoment significantly. Thus, the adverse effect of neutron-exposure can be passed on to unirradiated neighbourhood through irradiated blood tissue without involving cell-cell contact. The non-targeted radiation effect assumes greater consequences in radiotherapy and biodosimetry.
- 日本放射線影響学会の論文
著者
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Tanaka Kimio
Department Of Physics School Of Medicine Sapporo Medical University
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Tanaka Kimio
Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences
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KAMADA NANAO
Department of Cancer Cytogenetics
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Kamada N
Department Of Cancer Cytogenetics Research Institute For Radiation Biology And Medicine Hiroshima Un
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Kamada Nanao
広島大学原爆放射能医学研究所
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Kamada Nanao
Hiroshima Atomic Bomb Survivors Relief Foundation
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Tanaka K
Department Of Physics School Of Medicine Sapporo Medical University
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Tanaka K
Department Of Radiobiology Research Institute For Environmental Sciences
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Tanaka Kimio
Dep. Of Radiobiology Inst. For Environmental Sciences
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Tanaka Kimio
Department Of Biology Faculty Of Science Konan University
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Kamada Nanao
Research Institute For Radiation Biology &medicine Hiroshima Univ.
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Kamada Nanao
Department Of Hematology Research Institute For Nuclear Medicine & Biology Hiroshima University
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GAJENDIRAN NATARAJAN
Department of Cancer Cytogenetics, Research Institute for Radiation Biology and Medicine, Hiroshima
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Gajendiran Natarajan
Department Of Cancer Cytogenetics Research Institute For Radiation Biology And Medicine Hiroshima Un
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Kamada Nanao
Dept. Of Cancer Cytogenet. Res. Inst. Rad. Biol. &med. Hiroshima University.
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Tanaka Kimio
Res. Inst. Nuclear Med. Biol. Hiroshima Univ.
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