Gene Silencing of Tead3 Abrogates Radiation-induced Adaptive Response in Cultured Mouse Limb Bud Cells
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概要
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There is a crucial need to better understand the effects of low-doses of ionizing radiation in fetal models. Radiation-induced adaptive response (AR) was described in mouse embryos pre-exposed in utero to low-doses of X-rays, which exhibited lower apoptotic levels in the limb bud. We previously described AR-specific gene modulations in the mouse embryo. In this study, we evaluated the role of three candidate genes in the apoptotic AR in a micromass culture of limb bud cells: Csf1, Cacna1a and Tead3. Gene silencing of these three genes abrogated AR. Knowing that TEAD3 protein levels are significantly higher in adapted cells and that YAP/TAZ/TEAD are involved in the control of cell proliferation and apoptosis, we suggest that modulation of Tead3 could play a role in the induction of AR in our model, seen as a reduction of radiation-induced apoptosis and a stimulation of proliferation and differentiation in limb bud cells.
著者
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NAKAJIMA Tetsuo
National Laboratory for High Energy Physics
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Tanaka Kimio
Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences
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TAKI Keiko
Clinical Genetic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research
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Vares Guillaume
National Institute of Radiological Sciences
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Wang Bing
National Institute of Radiological Sciences
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Tanaka Kaoru
National Institute of Radiological Sciences
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SHANG Yi
National Institute of Radiological Sciences
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NENOI Mitsuru
National Institute of Radiological Sciences
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Tanaka K
Department Of Radiobiology Research Institute For Environmental Sciences
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