Effects of Prenatal Exposure to Low-dose β Radiation from Tritiated Water on the Neurobehavior of Mice
スポンサーリンク
概要
- 論文の詳細を見る
Pregnant adult C57BL/6J mice, randomly assigned to 1 of 4 groups, 3 of them were irradiated with β-rays from tritiated water(HTO) by a single intraperitoneal injection on the 12.5th day of gestation. Their offspring received cumulative doses of 0,5, 10 or 30 cGy in utero. Male pups were trained and examined using a set of behavioral tests that included avoidance acquisition and avoidance maintenance, open field test, hole-board dipping, a water maze, and a food labyrinth. Results were found for most parameters in the 10 and 30 cGy groups that differed significantly from results for the controls, indicating that the behavioral teratogenic effect of prenatal exposure to chronic β-ray radiation from HTO may be greater than the same dose of acute X- or γ-irradiation and that 10 cGy may be the lowest detectable dose level at which behavioral changes is detactable under the conditions used in this experiment.
- 日本放射線影響学会の論文
著者
-
Wang Bing
Department of Pathology, College of Medicine, School of Life Science and Technology, Xi’an Jiaotong
-
Wang Bing
National Institute of Radiological Sciences
-
Wang Bing
放射線医学総合研究所
-
Wang Bing
Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences
-
Zhou Xiang-yan
Department Of Radiation Toxicology Laboratory Of Industrial Hygiene Ministry Of Public Health
-
Wang B
Research Center For Radiation Safety Natl. Inst. Radiol. Sci.
-
Wang Bing
Department Of Biological And Chemical Engineering Gunma University
関連論文
- Adenine Sulfate Improves Cardiac Function and the Cardiac Cholinergic System After Myocardial Infarction in Rats
- Gene Silencing of Tead3 Abrogates Radiation-induced Adaptive Response in Cultured Mouse Limb Bud Cells
- Combined Treatment of Ionizing Radiation With Genistein on Cervical Cancer HeLa Cells
- Microarray Analysis of Differentially Expressed Genes in the Kidneys and Testes of Mice after Long-term Irradiation with Low-dose-rate γ-rays
- Induction of Rhodanese, a Detoxification Enzyme, in Livers from Mice after Long-term Irradiation with Low-dose-rate Gamma-rays
- Radiation hormesis : Stimulatory effects of low doses ionizing radiation
- Radiation-induced Apoptosis Responsible for Limb Teratogenesis in Embryonic Mice
- Radiation Induced Apoptosis in the Mouse Limb Bud Cells in vivo and in vitro
- 249 Prenatal Radiation-Induced Teratogenesis and Adaptive Response Modified by p53 and General Caspase Inhibitors(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Radiation-Induced Teratogenesis and Adaptive Response in the Late Period of Organogenesis in Mice : I. Dose Rate Effects
- Cleavage of RAD51 protein during apotosis.
- Effects of Caspase Inhibitors on Nuclear Protein NP95 Depletion Associated with Radiation-induced Apoptosis in Murine ThymicLymphoma 3SB Cells.
- Involvement of Protein Kinase C in Radiation-induced Apoptosis Regulation in 3SBH5 Cells
- Low-Dose Irradiation Mediates Ca^ Signaling in Cultured Rat Hepatocytes
- Rapid Decrease in the Expression of a Nuclear Protein NP95 Associated with Radiation-induced Apoptosis inMurine Thymic Lymphoma 3SB Cells.
- Involvement of Caspases in the Radiation-induced Apoptosis of Radiosensitive Murine Thymoma 3SB Cells
- Implication of Protein Kinase C Activation in the Radiation-Induced Apoptosis in Radiosensitive Murine Thymoma Cell 3SB
- Mechanisms for Radiation-induced Apoptosis in a Radiosensitive Murine Thymoma Cell Line 3SB
- 236 Distinct functions of protein kinase C subtypes in the regulation of radiation-induced apoptosis in murine thymic lymphoma cells(Apoptosis related, Abstracts of the 46th Annual Meeting of the Japan Radiation Research Society)
- Effect of 0.5 Gy Pre-expore on the PFC of Lethally Irradiated Mice
- Rescue of Lethally Irradiated Mice from Hematopoietic Death by Pre-expousure to 0.5 Gy X-rays withoutRecovery from Peripheral Blood Cell Depletion
- Fas-independent Apoptosis Induced by UVC in p53-Mutated Human Epithelial Tumor A431 Cells through Activation of Caspase-8 and JNK/SAPK
- Radioadaptation in Embryogenesis Is Related to p53 Gene Status
- Long Term Effects Observed in Mice Rescued by 0.5 Gy Pre-exposure from Lethal Irradiation
- UVC-induced Apoptosis in Human Epithelial Tumor A431 Cells : Sequence of Apoptotic Changes and Involvement of Caspase (-8 and -3) Cascade
- Radioadaptation in Embryogenesis during Late Period of Organogenesis and Postnatal Retardation in the Prenatally Primed Mice
- OK432-lnduced Modification of Radioadaptive Response in Mice
- Modification of Acquired Radio-Resistance in Mice by OK432
- OK432 Modification of Radio-Adaptive Response
- Removal Efficiency of the Combined Desulfurization/Denitration Process Using Powder-Particle Fluidized Bed
- Analysis or Radioresistant Variants Derived from 3SB Cell
- Effects of UVC-Irradiation on Cultured Mouse Limb Bud Cells
- Modification of Radiation-Induced Apoptosis Affects the Severity of Limb Teratogenesis in Embryonic Mice
- Gene Silencing of Tead3 Abrogates Radiation-induced Adaptive Response in Cultured Mouse Limb Bud Cells
- Effects of Prenatal Exposure to Low-dose β Radiation from Tritiated Water on the Neurobehavior of Mice
- Transcription Factor-recognition Sequences Potentially Involved in Modulation of Gene Expression after Exposure to Low-dose-rate γ-rays in the Mouse Liver
- Trp53 Activity Is Repressed in Radio-adapted Cultured Murine Limb Bud Cells
- Adenine Sulfate Improves Cardiac Function and the Cardiac Cholinerigic System After Myocardial Infarction in Rats