Microdosimetric Evaluation of Secondary Particles in a Phantom Produced by Carbon 290 MeV/nucleon Ions at HIMAC

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概要

• 論文の詳細を見る

• Microdosimetric single event spectra as a function of depth in a phantom for the 290 MeV/nucleon therapeutic carbon beam at HIMAC were measured by using a tissue equivalent proportional counter (TEPC). Two types of geometries were used : one is a fragment particle identification measurement (PID-mode) with time of flight (TOF) method without a backward phantom, and the other is an in-phantom measurement (IPM-mode) with a backward phantom. On the PID-mode geometry, fragments produced by carbon beam in a phantom are identified by the *E-TOF distribution between two scintillation counters positioned up- and down-stream relative to the tissue equivalent proportional counter (TEPC). Lineal energy distributions for carbon and five ion fragments (proton, helium, lithium, beryllium and boron) were obtained in the lineal-energy range of 0.1-1000 keV/μm at eight depths (7.9-147.9mm) in an acrylic phantom. In the IPM-mode geometry, the total lineal energy distributions measured at eight depths (61.9-322.9mm) were compared with the distributions in the PID-mode. Both spectra are consistent with each other. This shows that the PID-mode measurement can be discussed as the equivalent of the phantom measurement. The dose distribution of the carbon beam and fragments were obtained separately. In the depth dose curve, the Bragg peak was observed. Relative biological effectiveness (RBE) for the carbon beam in the acrylic phantom was obtained based on a biological response function as a lineal-energy. The RBE of carbon beam had a maximum of 4.5 at the Bragg peak. Downstream of the Bragg peak, the RBE rapidly decreases. The RBE of fragments is dominated by Boron particles around the Bragg peak region.

• 日本放射線影響学会の論文
• 2007-09-15

著者

• TAKADA Masashi

  National Institute of Radiological Sciences

• ENDO SATORU

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• HOSHI MASAHARU

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• 星 正治

  広島大学原爆放射能医学研究所 国際放射線情報センター

• 星 正治

  岡山理科大学 理学部応用物理学科

• 星 正治

  広島大学・原爆放射線医科学研究所国際放射線情報センター

• 静間 清

  広島大学大学院工学研究科

• Tanaka Kimio

  Department Of Physics School Of Medicine Sapporo Medical University

• 松浦 正明

  広島大学大学院工学研究科

• 星 正治

  広島大学原爆放射線医科学研究所・線量測定・評価研究分野

• Ishikawa Masayori

  広島大学原爆放射線医科学研究所 分子発がん制御研究分野

• 石川 正純

  北海道大学

• 石川 正純

  東京大学・原子力研究総合センター

• Ishikawa Masayori

  Department Of Medical Physics Hokkaido University Hospital

• 石川 正純

  東京大学大学院工学系研究科

• Tanaka Kimio

  Radiation Effect Mechanisms Research Group National Institute Of Radiological Sciences

• 遠藤 暁

  Mechanical System Engineering Graduate School Of Engineering Hiroshima University

• Endo Satoru

  Department Of Biochemistry Cancer Institute Okayama University Medical School

• ONIZUKA Yoshihiko

  Department of Health Science, Kyushu University

• SHIZUMA Kiyoshi

  Quantum Energy Applications, Graduated School of Engineering, Hiroshima University

• TANAKA Kenichi

  Research Institute for Radiation Biology and Medicine, Hiroshima University

• MAEDA Naoko

  Izumisano Hospital

• ISHIKAWA Masayori

  Hokkaido University Hospital

• MIYAHARA Nobuyuki

  National Institute of Radiological Science

• HAYABUCHI Naofumi

  Department of Radiology, School of Medicine, Kurume University

• Endo Satoru

  Research Institute Of Radiation Biology And Medicine Hiroshima University

• Endo Satoru

  Mechanical System Engineering Graduate School Of Engineering Hiroshima University

• Tanaka K

  Department Of Physics School Of Medicine Sapporo Medical University

• Tanaka K

  Department Of Radiobiology Research Institute For Environmental Sciences

• Tanaka Kimio

  Dep. Of Radiobiology Inst. For Environmental Sciences

• Endo Satoru

  Div. Environ. Biol. Res. Inst. Rad. Biol. And Med. Hiroshima University

• HOSHI M.

  RIRBM Hiroshima Univ.

• Hoshi Masaharu

  Res Inst. Nuclear Med. Biol. Hiroshima Univ.

• Hoshi Masaharu

  Research Institute For Nuclear Medecine And Biology Hiroshima University

• Shizuma Kiyoshi

  広島大学 工学研究科機械システム工学専攻

• Takada Masashi

  National Inst. Of Radiological Sciences

• Onizuka Yoshihiko

  Department Of Health Science Kyushu University

• Hayabuchi Naofumi

  Department Of Radiology Kurume University School Of Medicine

• Hayabuchi Naofumi

  Department Of Radiology School Of Medicine Kurume University

• 静間 清

  広島大学大学院工学部工学研究科

• Shizuma Kiyoshi

  Quantum Energy Applications Graduate School Of Engineering Hiroshima University

• Tanaka Kimio

  Dept. Of Cancer Cytogenet. Res. Inst. Rad. Biol. &med. Hiroshima University.

• Hoshi Masaharu

  Hiroshima University

• Tanaka Kenichi

  Department Of Physics School Of Medicine Sapporo Medical University

• Hayabuchi Naofumi

  Department Of Radiology Kurume University Hospital

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