Radiation-chemical Properties of the Hypoxic Cell Radiosensitizer Doranidazole (PR-350)

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概要

• 論文の詳細を見る

• This study was performed to confirm the radiation-chemical properties of the 2-nitroimidazole derivative doranidazole, (±)-(2RS, 3SR)-3-[(2-nitroimdazol-1-yl)-methoxy]butane-1, 2, 4-triol [CAS 137339-64-1], PR-350, which was synthesized as a hypoxic cell radiosensitizer with low toxicity. Radiation-chemical experiments using doranidazole showed that (1) unlike O_2, it had high reactivity toward not only hydrated electrons (e_<aq>^-), but also hydroxyl radicals (・OH), (2) the reduced intermediates of doranidasole had no ability to induce immediate strand breaks of colE1 plasmid DNA, (3) doranidazole enhanced radiation-induced DNA strand breaks of colE1 plasmid DNA in the aqueous state, whereas it did not enhance the base alteration, such as 8-oxo-deoxyguanosine, (4) it enhanced the radiation-induced formation of strand breaks with 3'- phosophate and 3'- phosphoglycolate termini, and (5) it was bound to DNA after irradiation. These facts revealed that the majority of radiation-chemical properties of doranidazole, except for the high reactivity toward ・OH, were similar to those of oxygen.

• 日本放射線影響学会の論文

著者

• TSUJITANI MICHIHIKO

  Pola Chemical Industries, Inc.

• KUWABARA MIKINORI

  Laboratory of Radiation Biology, Graduate School of Veterinary Medicine

• Iida Yoshiharu

  Laboratory Of Radiation Biology Graduate School Of Veterinary Medicine Hokkaido University

• Iida Yoshiharu

  北海道大学 獣医研究

• Yokoyama Kouji

  Pola Chemical Industries Inc.

• INANAMI Osamu

  Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of

• Sawamura Sadashi

  Division Of Quantum Energy Engineering Graduate School Of Engineering Hokkaido University

• Sawamura Sadashi

  Laboratory Of Applied Radiation Science Graduate School Of Engineering Hokkaido University

• Kuwabara Mikinori

  Laboratory Of Radiation Biology Graduate School Of Veterinary Medicine

• Kuwabara Mikinori

  Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V

• Inanami Osamu

  Laboratory Of Radiation Biology Department Of Environmental Veterinary Medical Sciences Graduate Sch

• Inanami Osamu

  Laboratory Of Radiation Biology Graduate School Of Veterinary Medicine Hokkaido University

• Kuwabara Mikinori

  Lab. Radiat. Biol. Grad. Sch. Vet. Med. Hokkaido Univ.

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