The Antiproliferative Effect of Bovine Lactoferrin on Canine Mammary Gland Tumor Cells
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概要
- 論文の詳細を見る
Lactoferrin has several biological activities, including antitumor activities in some human and animal tumor cells. Clinical trials have been carried out in human medicine based on these effects. However, the antitumor effects of lactoferrin in veterinary medicine remain unknown. In this in vitro study, we demonstrated that co-incubation of canine mammary gland tumor cells (CIPp and CHMp) and bovine lactoferrin induced growth arrest of tumor cells. This growth arrest was associated with induction of G1 arrest. Furthermore, this effect was stronger in tumor cells than in normal cells. These findings demonstrate that bovine lactoferrin has anti-tumor activity in canine mammary tumors and has the potential for use in tumor-bearing dogs.
著者
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Kuwabara Mikinori
Laboratory Of Radiation Biology Department Of Environmental Veterinary Sciences Graduate School Of V
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Inanami Osamu
Laboratory Of Radiation Biology Department Of Environmental Veterinary Medical Sciences Graduate Sch
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SATO Reeko
Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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KOBAYASHI Saori
Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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Yasuda Jun
Department Of Chemistry Graduate School Of Science Kyoto University
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Yamada Yuichi
Department Of Hygiene Kanazawa Medical University
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Momota Yutaka
Department Of Dermatology Chiba University School Of Medicine
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TOMIZAWA Nobuyuki
Departments of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University
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YAMADA Yuichi
Department of Veterinary Clinical Science, The United Graduate School of Veterinary Science, Gifu University
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HANKANGA Careen
Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University
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TOMIZAWA Nobuyuki
Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University
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KUWABARA Mikinori
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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SATO Reeko
Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University
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INANAMI Osamu
Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University
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KOBAYASHI Saori
Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University
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