Alcohol Consumption, Serum gamma-Glutamyltransferase Levels, and Coronary Risk Factors in a Middle-Aged Occupational Population

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概要

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• The relationships between alcohol consumption, serum gammaglutamyltransferase (GGT) levels, and the prevalence of major coronary risk factors were analyzed crosssectionally in 2,399 male and 1,402 female middle-aged workers, to clarify the effects of moderate alcohol consumption on the development of the metabolic syndrome. Male moderate drinkers, consuming less than 60 m/of alcohol per day, had a lower prevalence of upper body obesity and low serum HDL-cholesterolemia (LHDLC) in comparison with nondrinkers, but not of hypertension, impaired glucose tolerance or hypertriglyceridemia (HTG). In women, alcohol consumption did not show any significant associations with the coronary risk factors. Men with an elevated serum GGT (EGGT) of 40 U/lor above had a significantly higher odds ratio for all the coronary risk factors as compared with those with normal GGT, even after adjusting for alcohol consumption, together with age, body mass index, cigarette consumption and physical activity. Women with an EGGT of 25 U/l or above had similar findings, although significance was found only in HTG. Nearly 80% and 55% of the appearance of EGGT in men and women were attributable to alcohol consumption, and 20% and 10% of the male and female moderate drinkers had EGGT. These results suggest that even moderate alcohol consumption will increase coronary risk factors characteristic of the metabolic syndrome in drinkers who have an increase in serum GGT. Further studies are required to confirm the causal association between alcohol consumption, increase in serum GGT and development of the metabolic syndrome.

• 社団法人日本産業衛生学会の論文

著者

• Ishizaki Masao

  Department Of Social And Environmental Medicine Kanazawa Medical University

• Ishizaki Masao

  Department Of Social And Environmental Medicine (hygiene) Kanazawa Medical University.

• Ishizaki Masao

  Department Of Social And Environmental Medicine (hygiene) Kanazawa Medical University

• Ishida Masaaki

  Department Of Hygiene Kanazawa Medical University

• SUZUKI Hisa

  Department of Internal Medicine, Osaka City General Hospital

• Suzuki H

  Department Of Hygiene Kanazawa Medical University

• Suzuki Hisa

  Department Of Internal Medicine Osaka City General Hospital

• YAMADA Yuichi

  Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University

• Yamada Y

  Department Of Social And Environmental Medicine (hygiene) Kanazawa Medical University.

• Yamada Yuichi

  Department Of Mechanical Systems Engineering Musashi Institute Of Technology

• NOBORISAKA Yuka

  Department of Social and Environmental Medicine (Hygiene), Kanazawa Medical University.

• YAMADA Seiji

  Matsushita Science Center of Industrial Hygiene

• Suzuki Hisa

  Faculty Of Education Okayama University

• Yamada S

  Matsushita Science Center Of Industrial Hygiene

• Noborisaka Y

  Department Of Social And Environmental Medicine (hygiene) Kanazawa Medical University.

• Yamada Yuichi

  Department Of Hygiene Kanazawa Medical University

• Suzuki Hisa

  Department of Hygiene, Kanazawa Medical University

• ISHIZAKI Masao

  Department of Hygiene, Kanazawa Medical University

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