Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction

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概要

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• This study reported detailed clinical effects of bovine lactoferrin on 2 canine littermates (1 female and 1 male) with familial neutrophil dysfunction and an investigation of their genetic background. Clinical signs caused by severe upper respiratory bacterial infections were observed in these dogs. Oral administration of bovine lactoferrin for a long duration improved their clinical signs (severe uveitis in the female dog and coughing from pneumonia in the male dog). Their backcross dogs that have the same father didn’t show clinical signs of bacterial infection. Neutrophil function tests revealed that the backcross dogs didn’t have any disorders. It is likely that abnormal clinical signs are associated with neutrophil dysfunction in the colony, and the mother dog of these cases might be the genetic carrier of this dysfunction.

著者

• Abe Yuya

  Department Of Obstetrics And Gynecology Tohoku University School Of Medicine

• Oda Shinichi

  Department Of Animal Physiology Faculty Of Agriculture Tohoku University

• SATO Reeko

  Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University

• Sato Reeko

  Iwate Univ. Morioka

• KOBAYASHI Saori

  Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University

• Yasuda Jun

  Department Of Chemistry Graduate School Of Science Kyoto University

• KAMISHINA Hiroaki

  Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University

• ABE Yuya

  Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• SASAKI Juso

  Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• Oda Shinichi

  Department of Animal Science, Faculty of Agriculture, Iwate University

• KOBAYASHI Saori

  Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• KAMISHINA Hiroaki

  Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

• SATO Reeko

  Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University

• KOBAYASHI Saori

  Department of Small Animal Internal Medicine, Faculty of Agriculture, Iwate University

• KAMISHINA Hiroaki

  Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

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