Production of GM-CSF Mediated by Cysteine Protease of Der f in Canine Keratinocytes
スポンサーリンク
概要
- 論文の詳細を見る
House dust mite (HDM) allergens are the most common allergens for induction of IgE-mediated hypersensitivity. Recently, epicutaneous sensitization with HDM allergens has been emphasized in the development of atopic dermatitis (AD) by producing various soluble factors in keratinocytes. Among the soluble factors, GM-CSF is a key molecule that activates Langerhans cells, antigen-presenting cells in the epidermis. In the present study, we investigated the effects of Dermatophagoides farinae (Der f) on GM-CSF production in a canine keratinocyte cell line, CPEK. CPEKs were found to produce GM-CSF upon stimulation by Der f. The GM-CSF production was suppressed by addition of a cysteine protease inhibitor. The present results suggest that cysteine protease-derived Der f may be an initiator of allergic inflammation by inducing the production of GM-CSF in keratinocytes.
著者
-
Maeda Sadatoshi
Department Of Veterinary Internal Medicine Graduate School Of Agricultural And Life Sciences The Uni
-
KAMISHINA Hiroaki
Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University
-
KIMURA Tsuyoshi
The United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
-
SEKIDO Machiko
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
-
CHIMURA Naoki
The United Graduate School of Veterinary Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
-
SHIBATA Sanae
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
-
KONDO Naho
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
-
KAMISHINA Harumi
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1–1 Yanagido, Gifu 501–1193, Japan
-
SEKIDO Machiko
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
-
KIMURA Tsuyoshi
The United Graduate School of Veterinary Sciences, Gifu University
-
KONDO Naho
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
-
KAMISHINA Harumi
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
-
CHIMURA Naoki
The United Graduate School of Veterinary Sciences, Gifu University
-
SHIBATA Sanae
Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University
-
KAMISHINA Hiroaki
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida
関連論文
- Immunological Findings in 3 Dogs Clinically Diagnosed with Allergic Rhinitis
- Computer Tomography Diagnosis of Meningoencephalocele in a Calf
- Molecular Cloning of Canine Protease-Activated Receptor-2 and its Expression in Normal Dog Tissues and Atopic Skin Lesions
- Phenotypic Analysis for a Cell Line of Canine Epidermal Keratinocytes(Internal Medicine)
- Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs
- Suitable Reference Genes for Quantitative Real-Time RT-PCR in Total RNA Extracted from Canine Whole Blood Using the PAXgeneTM System
- Temporal Dynamic Changes of Phenotypic Expression of Peripheral CD4 Cells during Environmental Allergen Challenge in an Experimental Model of Canine Atopic Dermatitis: A Pilot Study
- Production of GM-CSF Mediated by Cysteine Protease of Der f in Canine Keratinocytes
- Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction
- Measurement for Canine IgE Using Canine Recombinant High Affinity IgE Receptor α Chain (FcεRIα)
- Efficacy of Fosfomycin on Escherichia coli Isolated from Bitches with Pyometra
- Magnetic Resonance Imaging Diagnosis of Dandy-Walker-Like Syndrome in a Wire-Haired Miniature Dachshund
- Genotyping Assays for the Canine Degenerative Myelopathy-Associated c.118G>A (p.E40K) Mutation of the SOD1 Gene Using Conventional and Real-Time PCR Methods: A High Prevalence in the Pembroke Welsh Corgi Breed in Japan
- Insulin and Glucagon Secretory Patterns during Propionate and Arginine Tolerance Tests in Japanese Black Cattle with Growth Retardation
- Expression Analysis of CCL27 and CCL28 mRNA in Lesional and Non-Lesional Skin of Dogs with Atopic Dermatitis
- Migration and Differentiation of Canine Bone Marrow Stromal Cells Transplanted into the Developing Mouse Brain