Migration and Differentiation of Canine Bone Marrow Stromal Cells Transplanted into the Developing Mouse Brain

スポンサーリンク

概要

• 論文の詳細を見る

• To evaluate whether canine bone marrow stromal cells (BMSCs) can migrate and adopt neural phenotypes in the developing mouse brain we transplanted fluorescently labeled BMSCs into the lateral ventricle of immunocompromised neonatal mice. Most fibroblasts, used as a control, and BMSCs isolated from adult dogs remained around the injection site and exhibited a spindle-shaped appearance. A small number of BMSCs from young dogs were found in the subventricular zone, rostral migratory stream, and olfactory bulbs, and retained expression of neuron marker. Our findings suggest that BMSCs isolated from adult dogs have limited ability of migration and differentiation toward neural cells in the developing brain. Bone marrow of young dogs may contain a primitive stem cell population with neural differentiation capacity.

• 公益社団法人 日本獣医学会の論文

著者

• KAMISHINA Hiroaki

  Department of Veterinary Clinical Medicine, Faculty of Agriculture, Iwate University

• CLEMMONS Roger

  Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

• MILNER Rowan

  Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

• FARESE James

  Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

• CHEESEMAN Jennifer

  Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

• KAMISHINA Hiroaki

  Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida

関連論文

• Immunohistochemical Observation of Canine Degenerative Myelopathy in Two Pembroke Welsh Corgi Dogs
• Suitable Reference Genes for Quantitative Real-Time RT-PCR in Total RNA Extracted from Canine Whole Blood Using the PAXgeneTM System
• Production of GM-CSF Mediated by Cysteine Protease of Der f in Canine Keratinocytes
• Clinical Effects of Bovine Lactoferrin on Two Canine Cases with Familial Neutrophil Dysfunction
• Magnetic Resonance Imaging Diagnosis of Dandy-Walker-Like Syndrome in a Wire-Haired Miniature Dachshund
• Genotyping Assays for the Canine Degenerative Myelopathy-Associated c.118G>A (p.E40K) Mutation of the SOD1 Gene Using Conventional and Real-Time PCR Methods: A High Prevalence in the Pembroke Welsh Corgi Breed in Japan
• Migration and Differentiation of Canine Bone Marrow Stromal Cells Transplanted into the Developing Mouse Brain

スポンサーリンク