Induction of Resistance to Etoposide and Adriamycin in a Human Glioma Cell Line Treated with Antisense Oligodeoxynucleotide Complementary to the Messenger Ribonucleic Acid of Deoxyribonucleic Acid Topoisomerase IIα
スポンサーリンク
概要
- 論文の詳細を見る
腫瘍細胞のTopo II阻害剤の耐性機序としてtopo IIの質的、量的変化、細胞膜蛋白の変化などの報告がある。我々はtopo IIαに注目し、topo IIα antisense oligodeoxynucleotideを用いてhuman glioma cell line (U373MG) のtopo IIαの発現のみを抑制し、それに伴う変化を検討した。topo IIα antisenseにてU373MGのtopo II活性がcontrolに比べ1/3に低下すると、細胞の形態、増殖能は変化しなかったが、topo II阻害剤であるetoposide、adriamycinに対して各々2.0倍、1.5倍の耐性化を示した。以上より、グリオーマ細胞においてtopo IIα発現はtopo II阻害剤の感受性を反映することが示唆された。
- 日本脳神経外科学会の論文
- 1997-09-15
著者
-
TAMIYA Takashi
Department of Neurological Surgery, Kagawa University Faculty of Medicine
-
Matsumoto Kengo
Department of Cardiology, National Hospital Organization Kure Medical Center, Chugoku Cancer Center
-
栗山 充夫
岡山大学医学部脳神経外科
-
Tamiya Takashi
Department Of Neurological Surgery Okayama University Medical School
-
ONO Yasuhiro
Department of Applied Physics, Graduate School of Engineering, Tohoku University
-
OHMOTO Takashi
Department of Neurological Surgery,Okayama University Medical School
-
Tsutsui Ken
Department of Molecular Biology. Okayama University Medical School.
-
Ohmoto Takashi
Department Of Neurological Surgery Okayama University Medical School
-
Matsumoto Kengo
Department Of Cardiology National Hospital Organization Kure Medical Center
-
Matsumoto Kengo
Department Of Neurological Surgery Okayama University Medical School
-
FURUTA Tomohisa
Department of Clinical Psychology, School of Social Welfare, Kibi International University
-
Tsutsui Kimiko
Third Department Of Anatomy Okayama University Medical School
-
Furuta Tomohisa
Department Of Neurological Surgery Okayama University Medical School
-
Furuta Tomohisa
Department Of Biochemistry Fukushima Medical University
-
栗山 充夫
岡山大学 脳神経外科
-
Tamiya Takashi
Department Of Neurological Surgery Faculty Of Medicine Kagawa University
-
Tsutsui Ken
Department Of Biochemistry Cancer Institute Okayama University Medical School
-
Ono Yasuhiro
Department Of Applied Chemistry Faculty Of Engineering & High Technology Research Center Kansai
-
Ono Yasuhiro
Department Of Neurological Surgery Okayama University Medical School
-
Ohmoto Takashi
Department Of Neurological Surgery Kagawa Medical School
-
OHMOTO Takashi
Department of Environmental Technology, Osaka Municipal Technical Research Institute
関連論文
- Seizure Suppression in Amygdala-Kindled Mice by Transplantation of Neural Stem/Progenitor Cells Derived From Mouse Embryonic Stem Cells
- 小線源による低線量率持続放射線照射及び温熱併用のグリオーマ培養細胞に及ぼす影響 : 方法の確立と温熱の併用
- PE-511 An Effect of Japanese Recipes of the DASH Diet on Blood Pressure, Glucose and Metabolism(Hypertension, clinical-07, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-693 The Prelevance of Metabolic Syndrome for Coronary Artery Disease(CAD)(Diabetes/Obesity/Metabolic syndrome-13 (H) PJ116,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-379 Impact of Plasma Adiponectin Concentration on Coronary Artery Disease in Japanese Type 2 Diabetic Subjects(Diabetes/Obesity/Metabolic syndrome-9 (H) PJ64,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circu
- 著明なdesmoplasiaを伴った松果体部腫瘍の1例
- Reversible Magnetic Resonance Imaging Changes Associated With Hypoglycemia : Case Report
- OE-060 Apo B-48 Is a Good Marker for Coronary Risk and Impaired Metabolism of Chylomicron Remnants in Subjects with Metabolic Syndrome(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Ci
- Modulated Structure of Misfit-Layered Cobalt Oxide [Ca_2(Co_Cu_)_2O_4]_CoO_2
- Preparation and Low-Temperature Thermoelectric Properties of the Composite Crystal [Ca_2(Co_Cu_)_2O_4]_CoO_2 : Structure and Machanical and Thermal Properties of Condensed Matter
- Low-Temperature Synthesis and Electric Properties of New Layered Cobaltite, Sr_xCoO_2 : Electrical Properties of Condensed Matter
- 15. Long Term Follow-up Study of 34 Cases of the Spasmodic Torticollis
- Mechanical Thrombolysis for Treatment of Acute Sinus Thrombosis : Case Report
- Improvement of Cerebral Arterial Stenosis Associated With Basedow's Disease : Case Report
- Parietal Lipomeningocele : Case Report
- Disappearance of Hemifacial Spasm After Ventriculoperitoneal Shunting in a Patient With Achondroplasia : Case Report
- Evaluation of tumor FDG transport and metabolism in primary central nervous system lymphoma using [^F]fluorodeoxyglucose (FDG) positron emission tomography (PET) kinetic analysis
- Modulated Structure of the Thermoelectric Compound [Ca_2CoO_3]_CoO_2
- Low-Temperature Thermoelectric Properties of the Composite Crystal[Ca_2CoO_]_[CoO_2]
- MEM Analysis on Electron Density Distribution of Superconductors, Pb_2Sr_2Y_Sr_Cu_3O_8, Pb_2Sr_2Y_Ca_xCu_3O_8(x=0.25 and 0.41)and Pb_2Sr_2Ho_Ca_Cu_3O_8
- Structural, Magnetic and Thermoelectric Properties of Delafossite-type Oxide, CuCr_Mg_xO_2 (0 ≦ x ≦ 0.05)
- UPSTREAM ELEMENT OF THE SEA URCHIN ARYLSULFATASE GENE SERVES AS AN INSULATOR(Developmental Biology)(Proceedings of the Seventieth Annual Meeting of the Zoological Society of Japan)
- PJ-678 The Effect of Adiponectin on the Severity of Coronary Artery Disease(Diabetes / Obesity / Metabolic syndrome(14)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Marked Differences In Visceral Fat Accumulation-Related Cardiovascular Risk Factors between Young and Elderly Patientswith Coronary Artery Disease
- Adiponectin is a Predictive Visceral Fat Accumulation-Related Cardiovascular Risk Factor
- 巨大インスリノーマのあった多内分泌腺腫症1型の1例
- Dipole analysis in a case with tumor-related epilepsy
- IS118 Reduced Secretion of Tumor Necrosis Factor-a and Interleukin-1b from Monocyte-Macrophages of CD36-Deficient Subjects
- Efficient Microbial Degradation of Bisphenol A in the Presence of Activated Carbon(ENVIRONMENTAL BIOTECHNOLOGY)
- Mode of Action on Deacetylation of Acetylated Methyl Glycoside by Cellulose Acetate Esterase from Neisseria sicca SB
- Role of Endo-l,4-β-glucanases from Neisseria sicca SB in Synergistic Degradation of Cellulose Acetate(Biochemistry & Molecular Biology)
- Purification and Characterization of an Endo-1,4-β-glucanase from Neisseria sicca SB that Hydrolyzes β-1,4 Linkages in Cellulose Acetate(Biochemistry & Molecular Biology)
- Periodic distributions on C^*-algebras
- Usefulness of [^F]FDG-PET kinetic analysis in non-enhancing primary central nervous system lymphoma : Case report
- Crossed cerebellar glucose hypermetabolism demonstrated using PET in symptomatic epilepsy : Case report
- Resistance to topoisomerase ll inhibitors in human glioma cell lines overexpressing multidrug resistant associated protein (MRP) 2
- Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients
- 38. Clinical and Neurophysiological Investigation of the Preventive Effect to Convulsive Seizure by Means of Administration of GABA(γ-aminobutylic acid) Derivatives to CSF Cavity
- Proliferative Potential and Apoptosis in Rat Glioma Cell Lines after Hyperthermia
- Intraparenchymal Metastatic Tumor with Periventricular Dissemination : Case Report
- 14. Three Cases of Myoclonus Epilepsy
- Operative Results of Ruptured Intracranial Aneurysms in Aged Patients
- Qualitative and Quantitative Analyses of Postformalin Ammoniacal Silver Staining of Histones
- Analysis of CD8 T-cell response by IFNγ ELISPOT and H-2L^d/pRL1a tetramer assays in pRL1a multiple antigen peptide-immunized and RL male 1-bearing BALB/c and (BALB/c×C57BL/6) F_1 mice
- Phase Transitions in Mixed Crystal System K_(NH_4)_xH_2PO_4
- Structure Refinements of the Mixed Crystal K_(NH_4)_H_2PO_4 in the Temperature Range from 20 K to 250 K
- Effect of Hydorostatic Pressure on the Ferroelectric Phase Transition in KH_2AsO_4
- Phase Transitions in Mixed Crystal System (NH_4)_2(BeF_4)_(SO_4)_x
- 300-800℃および1kbにおける花崗閃緑岩JG-1aと2MNaCl水溶液間の元素分配実験
- Local Administration of Human Fibroblast Interferon (Hu IFN-β) for Metastatic Brain Tumor
- New Method for the Evaluation of the Response of Cultured Cell Lines to Continuous Low-dose-rate Irradiation from Encapsulated Iridium-192 Seeds with Hyperthermia
- Thermal Damage Threshold of Brain Tissue : Histological Study of Heated Normal Monkey Brains
- Regional differences in the expression of DNA topoisomerase IIβ in the pyramidal neurons of the rat hippocampus
- Glioblastoma With Metastasis to the Spleen(Case Report)
- A monoclonal antibody that recognizes ganglioside GD_ in the rat central nervous system
- Induction of Resistance to Etoposide and Adriamycin in a Human Glioma Cell Line Treated with Antisense Oligodeoxynucleotide Complementary to the Messenger Ribonucleic Acid of Deoxyribonucleic Acid Topoisomerase IIα
- Anthraquinones from Neonauclea calycina and Their Inhibitory Activity against DNA Topoisomerase II
- INHIBITORY ACTIVITY OF XANTHONE DERIVATIVES ISOLATED FROM SOME GUTTIFERAEOUS PLANTS AGAINST DNA TOPOSIOMERASES I AND II
- X-Ray Diffraction Study of LaBSiO_5
- Immunocytochemical Approach to Virus-Induced Brain Tumors : From the Aspect of T (Tumor) Antigen
- Purification and Characterization of an Esterase Involved in Poly (vinyl alcohol) Degradation by Pseudomonas vesicularis PD
- Expression dynamics and functional implications of DNA topoisomerase IIβ in the brain
- Large Supratentorial Ectopic Ependymoma With Massive Calcification and Cyst Formation : Case Report
- Immunohistochemical characterization of the suprachiasmatic nucleus and the intergeniculate leaflet in the hereditary bilaterally microphthalmic rat
- Combined Brachytherapy and External Beam Radiotherapy in Normal Monkey Brains : Experimental Radiation Necrosis Evaluated by Sequential Magnetic Resonance Imaging
- The effect of intrastriatal single injection of GDNF on the nigrostriatal dopaminergic system in hemiparkinsonian rats:behavioral and histological studies using two different dosages
- Organic Field-effect Transistor Based on a Thin Film of Polydiacetylene Prepared from 10,12-Pentacosadiynoic Acid
- Combination of Serum Adiponectin Level and Metabolic Syndrome is Closely Associated with Coronary Artery Disease in Japanese Subjects with Good Glycemic Control
- Non-commutative lens spaces
- Selection and Combination of Techniques for Treating Spontaneous Carotid-cavernous Sinus Fistulas
- Effect of Adjuvant Iridium-192 Brachytherapy on the Survival of Patients with Malignant Gliomas
- Effects of Prolonged Treatment with β-Adrenoceptor Antagonist, Carteolol on Systemic and Regional Hemodynamics in Stroke-Prone Spontaneously Hypertensive Rats
- Use of PET in the diagnosis of primary CNS lymphoma in patients with atypical MR findings
- Factors Influencing the Recurrence Rate of Intracranial Meningiomas after Surgery
- Trifluoromethanesulfonic Anhydride-Promoted α-Bromination of Ketones with Grignard Reagent or Magnesium Bromide
- Ascending Pharyngeal-vertebral Anastomosis with Bilateral Absence of Vertebral Arteries : Case Report
- Pineocytoma With Massive Intratumoral Hemorrhage After Ventriculoperitoneal Shunt : Case Report
- Resection of Deep-seated Gliomas Using Neuroimaging for Stereotactic Placement of Guidance Catheters
- Acute Effects of Interstitial Hyperthermia on Normal Monkey Brain : Magnetic Resonance Imaging Appearance and Effects on Blood-Brain Barrier
- Preliminary Results of Interstitial ^<192>Ir Brachytherapy for Malignant Gliomas
- 11. In Some Aspect of Electrical Stimulation of the Ventrolateral Nucleus and the Centromedian of the Human Thalamus
- 2. Ambient Cistern as a Intracerebral Reference Point for Thalamotomy
- Naturalized Epistemology and Its Problems
- Epistemology in Japan : 2000-2005
- Distributions associated with $C^\ast$-dynamical systems
- Metastasis of renal cell carcinoma to central nervous system hemangioblastoma in two patients with von Hippel-Lindau disease
- Cerebral Vasospasm following Subarachnoid Hemorrhage : Experimental and Clinical Studies
- Dimension groups for subshifts and simplicity of the associated C^*-algebras
- Hemifacial Spasm Due to Cerebellopontine Angle Epidermoid Tumor : Case Report
- Shannon graphs, subshifts and lambda-graph systems
- Operative Indication of Unruptured Cerebral Aneurysms Based on the Natural History
- Biodegradation of Bisphenol A and Related Compounds by Sphingomonas sp. Strain BP-7 Isolated from Seawater
- Purification and Characterization of an Esterase Involved in Cellulose Acetate Degradation by Neisseria sicca SB
- Experimental Analysis of Brain Surface Elastance in Cats
- Combined Use of Electrolytically and Mechanically Detachable Platinum Coils for Endovascular Treatment of Cerebral Aneurysms : Technical Note
- 6. A Case of Juvenile Parkinsonism Combined with Epileptic Abnormality (PROCEEDINGS OF THE Vth ANNUAL MEETING OF THE JAPAN SOCIETY FOR RESEARCH IN STEREOENCEPHALOTOMY)
- 12. Dyskinesia Produced by L-Dopa in Monkeys with Tegmental Lesions and Resting Tremor
- Usefulness of L-[Methyl-^C]Methionine Positron Emission Tomography in the Treatment of Idiopathic Hypertrophic Cranial Pachymeningitis : Case Report
- Anti-inflammatory Effect of D-Allose in Cerebral Ischemia/Reperfusion Injury in Rats
- Non-commutative three dimensional spheres