Acute Effects of Interstitial Hyperthermia on Normal Monkey Brain : Magnetic Resonance Imaging Appearance and Effects on Blood-Brain Barrier
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概要
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The magnitude and time course of histological and neuroradiological changes due to interstitial hyperthermia in normal cerebral white matter were investigated in eight adult Japanese monkeys. A cooling system enveloping a 2450-MHz microwave antenna was inserted stereotactically into the brain under general anesthesia. A point located 5mm away from the surface of the cooling system was used as the reference point (RP). Hyperthermia was given to maintain the RP at 43℃ for 60 minutes. Two animals were sacrificed under general anesthesia following the intravenous administration of Evans blue, immediately and 1, 3, and 7 days after treatment. After removing the brain, histological changes were investigated. Magnetic resonance (MR) imaging was performed at 1, 3, and 7 days after treatment. Evans blue extravasation was most prominent in the region heated to 43℃ or above immediately after treatment. MR imaging showed obvious enhancement in the region heated to 43℃ or above 1 day after treatment, related to the disruption of the blood-brain barrier (BBB) by hyperthermia. Three days after treatment, ring-like enhancement with a central low-intensity area was seen in the region heated to about 43℃, caused by BBB disruption and slight neovascularization. One week after treatment, an enhanced ring was observed in the region heated to less then 43℃ which surrounded a low-intensity area. The enhancement seen 1 week after treatment was caused by prominent neovascularization. T_2-weighted imaging showed a high-intensity area, caused by edema, most prominent 3 days after treatment. Thus chemotherapeutic agents should be given just before the end of hyperthermia.
- 日本脳神経外科学会の論文
- 1994-10-15
著者
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松本 健五
信州大学 脳神経外科
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Ohmoto Takashi
Department Of Neurological Surgery Okayama University Medical School
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Matsumoto Kengo
Department Of Cardiology National Hospital Organization Kure Medical Center
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Higashi Hisato
Department Of Neurological Surgery Okayama University Medical School
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NAKAGAWA MINORU
Department of Neurological Surgery
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Furuta Tomohisa
Department Of Neurological Surgery Okayama University Medical School
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Furuta Tomohisa
Department Of Biochemistry Fukushima Medical University
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Nakagawa Minoru
Department Of Neurological Surgery Okayama University Medical School
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Ohmoto Takashi
Department Of Neurological Surgery Kagawa Medical School
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FURUTA Tomohisa
Department of Neurological Surgery, Okayama, University Medical School
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OHMOTO Takashi
Department of Neurological Surgery, Okayama University Medical, School
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OHMOTO Takashi
Department of Environmental Technology, Osaka Municipal Technical Research Institute
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