New Method for the Evaluation of the Response of Cultured Cell Lines to Continuous Low-dose-rate Irradiation from Encapsulated Iridium-192 Seeds with Hyperthermia
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概要
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A new method was designed to investigate and evaluate the biological effectiveness of hyperthermia combined with continuous low-dose-rate irradiation (CLDRI) from encapsulated iridium-192 seed sources on glioma cells in vitro using the MTT assay. The system consists of 10 iridium seeds contained in a catheter bent into a circle, which is placed on a culture plate containing the cells. The effects of CLDRI and CLDRI combined with hyperthermia on a cultured rat glioma cell line (C-6) were studied. The number of surviving cells decreased as the total radiation dose increased. There was no significant difference in survival rates at dose rates of 0.1 Gy/hr and of 0.2 Gy/hr (p = 0.2811). An additive effect was observed in the cells treated with hyperthermia at 41℃ and 42℃, combined with CLDRI, and a synergistic effect between the two treatment modalities was observed at 43℃. This new device is less expensive, easily reproducible, and can also be performed easily enough to examine a large number of samples in a short time period for sensitivity testing.
- 日本脳神経外科学会の論文
- 1997-04-15
著者
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Adachi Hisashi
Department of Cardio-Vascular Medicine, Kurume University School of Medicine
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芦立 久
岡山大学脳神経外科
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松本 健五
信州大学 脳神経外科
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Matsumoto Kengo
Department of Cardiology, National Hospital Organization Kure Medical Center, Chugoku Cancer Center
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OHMOTO Takashi
Department of Neurological Surgery,Okayama University Medical School
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KUNISHIO Katsuzo
Departments of Neurological Surgery,Kagawa University School of Medicine,Kagawa
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Ohmoto Takashi
Department Of Neurological Surgery Okayama University Medical School
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Matsumoto Kengo
Department Of Cardiology National Hospital Organization Kure Medical Center
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Adachi Hisashi
Department Of Neurological Surgery Okayama University Medical School
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FURUTA Tomohisa
Department of Clinical Psychology, School of Social Welfare, Kibi International University
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Furuta Tomohisa
Department Of Neurological Surgery Okayama University Medical School
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Furuta Tomohisa
Department Of Biochemistry Fukushima Medical University
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芦立 久
Department Of Neurological Surgery Okayama University Medical School
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Kunishio Katsuzo
Department Of Neurological Surgery Okayama University Medical School Okayama
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Kunishio Katsuzo
Department Of Neurological Surgery Kagawa Medical University
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Ohmoto Takashi
Department Of Neurological Surgery Kagawa Medical School
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FURUTA Tomohisa
Department of Neurological Surgery, Okayama, University Medical School
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OHMOTO Takashi
Department of Neurological Surgery, Okayama University Medical, School
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OHMOTO Takashi
Department of Environmental Technology, Osaka Municipal Technical Research Institute
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