Technetium-99m Sestamibi Single Photon Emission Computed Tomography Findings Correlated With P-glycoprotein Expression, Encoded by the Multidrug Resistance Gene-1 Messenger Ribonucleic Acid, in Intracranial Meningiomas
スポンサーリンク
概要
- 論文の詳細を見る
The present study evaluated whether technetium-99m sestamibi (^<99m>Tc-MIBI) single photon computed tomography (SPECT) characteristics of intracranial meningioma are correlated with the histological malignancy, proliferative potential, and P-glycoprotein (Pgp) expression, encoded by the multidrug resistance gene-1 (MDR-1) messenger ribonucleic acid (mRNA). Twenty-one patients with intracranial meningiomas, including 17 benign and four nonbenign meningiomas, underwent ^<99m>Tc-MIBI SPECT imaging at 15 minutes (early) and 3 hours (delayed) after injection. The tumor-to-normal pituitary gland ratio was calculated on both early (ER) and delayed (DR) images. Retention index (RI) was calculated using the following formula: (DR - ER)/ER × 100%. Meningioma specimens were examined by immunohistochemistry using anti-Pgp and MIB-1 monoclonal antibody. MDR-1 mRNA expression was also investigated using reverse transcription-polymerase chain reaction assay. ^<99m>Tc-MIBI was highly accumulated and retained in the tumors. ^<99m>Tc-MIBI SPECT findings were not related to MIB-1 labeling index. ^<99m>Tc-MIBI SPECT RI of the Pgp-positive group (-9.12 ± 22.27%) was significantly lower than that of the Pgp-negative group (28.79 ± 22.80%) (p = 0.0016). No significant difference was seen in ER and DR between the positive and negative groups. These results show that ^<99m>Tc-MIBI may not be useful for determining proliferative potential and histological malignancy, but could predict anticancer drug resistance related to the expression of MDR-1 mRNA and its gene product Pgp in patients with intracranial meningiomas.
- 日本脳神経外科学会の論文
- 2003-12-15
著者
-
MATSUMOTO Yoshihito
Department of Neurological Surgery, Kagawa University Faculty of Medicine
-
NAGAO Seigo
Department of Neurological Surgery, Kagawa University Faculty of Medicine
-
Nagao Seigo
香川大学 医学部脳神経外科
-
Nagao Seigo
Department Of Neurological Surgery Kagawa University Faculty Of Medicine
-
Nagao S
Department Of Neurological Surgery Kagawa University School Of Medicine
-
Nagao S
Department Of Neurological Surgery Kagawa University
-
Nagao Seigo
Department Of Neurological Surgery Kagawa Medical School
-
Nagao Seigo
Department Of Neurological Surgery Kagawa University School Of Medicine
-
KUNISHIO Katsuzo
Departments of Neurological Surgery,Kagawa University School of Medicine,Kagawa
-
MORISAKI Kuniaki
Departments of Neurological Surgery, Kagawa Medical University
-
NlSHIYAMA Yoshihiro
Departments of Radiology, Kagawa Medical University
-
Matsumoto Yoshihito
Department Of Neurological Surgery Kagawa University Faculty Of Medicine
-
Kunishiro Katsuzou
Departments Of Neurological Surgery Kagawa University School Of Medicine Kagawa
-
Kunishio Katsuzo
Department Of Neurological Surgery Kagawa Medical University
-
Nlshiyama Yoshihiro
Departments Of Radiology Kagawa Medical University
-
Morisaki Kuniaki
Departments Of Neurological Surgery Kagawa Medical University
関連論文
- Seizure Suppression in Amygdala-Kindled Mice by Transplantation of Neural Stem/Progenitor Cells Derived From Mouse Embryonic Stem Cells
- Spinal Cord Hemangioblastoma Presenting with Subarachnoid Hemorrhage : Case Report
- Inhibition of Topoisomerase II α Subunit De Novo Synthesis by Specific Antisense Oligonucleotides Suppresses Human Gliomo T98G Cell Growth
- Magnetic resonance imaging and positron emission tomography findings in status epilepticus following severe hypoglycemia
- Mechanical Thrombolysis for Treatment of Acute Sinus Thrombosis : Case Report
- Improvement of Cerebral Arterial Stenosis Associated With Basedow's Disease : Case Report
- Parietal Lipomeningocele : Case Report
- Disappearance of Hemifacial Spasm After Ventriculoperitoneal Shunting in a Patient With Achondroplasia : Case Report
- Evaluation of tumor FDG transport and metabolism in primary central nervous system lymphoma using [^F]fluorodeoxyglucose (FDG) positron emission tomography (PET) kinetic analysis
- Preoperative Identification of Subthalamic Nucleus for Deep Brain Stimulation Using Three-dimensional Phase Sensitive Inversion Recovery Technique
- Embryonic transplantation and ischemic memory deficit
- Radiology Manifestation of Spinal Accessory Neurinoma: A Case Report
- Transvenous Embolization of High Flow Carotid Cavernous Fistula : A Case Report
- Usefulness of [^F]FDG-PET kinetic analysis in non-enhancing primary central nervous system lymphoma : Case report
- Crossed cerebellar glucose hypermetabolism demonstrated using PET in symptomatic epilepsy : Case report
- Resistance to topoisomerase ll inhibitors in human glioma cell lines overexpressing multidrug resistant associated protein (MRP) 2
- Expression of Matrix Metalloproteinse-9 in Thrombin-Induced Brain Edema Formation in Rats
- Craniopharyngiomas With Intratumoral Hemorrhage : Two Case Reports
- Technetium-99m Sestamibi Single Photon Emission Computed Tomography Findings Correlated With P-glycoprotein Expression, Encoded by the Multidrug Resistance Gene-1 Messenger Ribonucleic Acid, in Intracranial Meningiomas
- Incidence of Mutation and Deletion in Topoisomerase IIα mRNA of Etoposide and mAMSA-resistant Cell Lines
- Altered Topoisomerase IIα and Multidrug Resistance-associated Protein Levels during Drug Selection : Adaptations to Increasing Drug Presure
- Expression of Drug Resistance Genes in VP-16 and mAMSA-selected Human Carcinoma Cells
- Neuropsychological Outcome and Social Recovery of Head-injured Patients
- Proliferative Potential and Apoptosis in Rat Glioma Cell Lines after Hyperthermia
- Hypophosphorylation of Topoisomerase IIα in Etoposide (VP-16)-resistant Human Carcinoma Cell Lines Associated with Carboxy-terminal Truncation
- S-I-12. The Effects of Decompressive Craniectomy on Brain Water Content for Acute Brain Selling
- New Method for the Evaluation of the Response of Cultured Cell Lines to Continuous Low-dose-rate Irradiation from Encapsulated Iridium-192 Seeds with Hyperthermia
- Prediction of Motor Function by Magnetic Brain Stimulation in Patients with Intracerebral Hematoma
- Factors Influencing the Recurrence Rate of Intracranial Meningiomas after Surgery
- Balloon-assisted Coll Placement in Wide-necked Cerebral Aneurysms: Preliminary Clinical Experience
- Endovascular Treatment of Basilar Tip Aneurysm Associated With Moyamoya Disease
- Stereotactically Inserted Tube-Guided Brain Biopsy Using Positron Emission Tomography and Magnetic Besonance Coregistered Images : Case Report
- Extracranial Vertebral Artery Aneurysm Causing Spinal Subarachnoid Hemorrhage : Case Report
- Reduction of expression of the multidrug resistance protein (MRP)1 in glioma cells by antisense phosphorothioate oligonucleotides
- Operative Indication of Unruptured Cerebral Aneurysms Based on the Natural History
- Guidelines for the Management of Severe Head Injury, 2nd Edition Guidelines from the Guidelines Committee on the Management of Severe Head Injury, the Japan Society of Neurotraumatology
- Matrix metalloproteinase-9 expression in human traumatic brain injury
- FDG-PET findings of the brain in lymphomatoid granulomatosis