Proliferative Potential and Apoptosis in Rat Glioma Cell Lines after Hyperthermia
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概要
- 論文の詳細を見る
The proliferative potential of cultured rat glioma cell(C6 and 9L)was evaluated after hyperthermia using immunohistochemical staining with bromodeoxyuridine(BrdU)and Ki-67 monoclonal antibodies. Apoptosis was assessed by in situ end-labeling of deoxyribonucleic acid breaks. Both BrdU and Ki-67 labeling indexes decreased with increasing hyperthermia time. The decrease of the Ki-67 labeling index was not as great as that of the BrdU labeling index. The number of apoptotic cells increased with time after hyperthermia. These results indicate that the antitumor effect of hyperthermia may reflect the induction of apoptosis in the cells within the cell cycle, and the resultant reduction of the proliferative potential of surviving cells, especially in the S phase.
- 日本脳神経外科学会の論文
- 1998-04-15
著者
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TAMIYA Takashi
Department of Neurological Surgery, Kagawa University Faculty of Medicine
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松本 健五
信州大学 脳神経外科
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Matsumoto Kengo
Department of Cardiology, National Hospital Organization Kure Medical Center, Chugoku Cancer Center
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Tamiya T
Okoyama Univ. Graduate School Of Medicine And Density Okayama Jpn
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Tamiya Takashi
国立病院機構岩国医療センター 脳神経外科
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OHMOTO Takashi
Department of Neurological Surgery,Okayama University Medical School
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KUNISHIO Katsuzo
Departments of Neurological Surgery,Kagawa University School of Medicine,Kagawa
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Ohmoto Takashi
Department Of Neurological Surgery Okayama University Medical School
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Matsumoto Kengo
Department Of Cardiology National Hospital Organization Kure Medical Center
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Rong-yao Liu
Department Of Neurological Surgery Okayama University Medical School
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FURUTA Tomohisa
Department of Clinical Psychology, School of Social Welfare, Kibi International University
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MIZUMATSU Shinichiro
Department of Neurological Surgery, Okayama University Medical School
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Mizumatsu Shinichiro
Department Of Neurological Surgery Okayama University Medical School
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Furuta Tomohisa
Department Of Neurological Surgery Okayama University Medical School
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Furuta Tomohisa
Department Of Biochemistry Fukushima Medical University
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Tamiya Takashi
Department Of Neurological Surgery Faculty Of Medicine Kagawa University
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Kunishio Katsuzo
Department Of Neurological Surgery Okayama University Medical School Okayama
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Kunishio Katsuzo
Department Of Neurological Surgery Kagawa Medical University
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Ohmoto Takashi
Department Of Neurological Surgery Kagawa Medical School
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劉 榮耀
Department of Neurological Surgery , Okayama University Medical, School
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FURUTA Tomohisa
Department of Neurological Surgery, Okayama, University Medical School
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OHMOTO Takashi
Department of Neurological Surgery, Okayama University Medical, School
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OHMOTO Takashi
Department of Environmental Technology, Osaka Municipal Technical Research Institute
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