Immunocytochemical Approach to Virus-Induced Brain Tumors : From the Aspect of T (Tumor) Antigen
スポンサーリンク
概要
- 論文の詳細を見る
Recently isolated human papovaviruses such as JC and BK viruses are not only antigenically related to SV40, but also neuro-oncogenic in experimental animals. Cells transformed in vitro or brain tumors induced by these viruses are usually free of infectious virus. However, the causual relationship between the tumor or transformed cells and the viruses can be immunocytochemically demonstrated by the presence of virus-specific non-virion antigens such as T (tumor) antigen. In the present study, the authors successfully applied a sensitive enzyme-labelled antibody method using Fab' fragment to localizing T antigens in SV40 or BK virus-induced brain tumors and infected cells. T antigens of SV40 and BK virus are immunocytochemically indistinguishable. Positive staining for T antigen is seen as a granular pattern in the tumor cell nuclei, but not the nucleoli, in the interphase and it appears as a loose network of electron-dense reaction precipitates associated with nuclear chromatin, whereas the chromosomes in mitosis do not seem to be tagged with immunoperoxidase reaction products for T antigens. On the other hand, T antigen is first observed in the cytoplasm of SV40-infected cells as early as 3 hours postinfection with subsequent transport to the nuclei within 24 hours. The intensity of staining of T antigen is markedly reduced because of maturation of virions in the infected cell nuclei 24 hours after infection. The authors believe that extensive studies of papovavirus T antigens are necessary to elucidate papovavirus oncology and may provide more information regarding possible viral etiology of human tumors of the central nervous system.
- 日本脳神経外科学会の論文
- 1981-01-15
著者
-
TABUCHI Kazuo
Department of Neurosurgery, Saga Medical School
-
Tabuchi Kazuo
Department Of Neurological Surgery Okayama University Medical School
-
TSUBOI Masahiro
Department of Diagnostic Radiology, Tohoku University School of Medicine
-
NISHIMOTO Akira
Department of Neurological Surgery,Okayama University Medical School
-
Nishimoto Akira
Department Of Neurological Surgery Okayama University Medical School
-
Moriya Yoshio
Department Of Neurological Surgery Okayama University Medical School
-
Moriya Yoshio
Department Of Materials Engineering And Applied Chemistry Mining College Akita University
-
FURUTA Tomohisa
Department of Clinical Psychology, School of Social Welfare, Kibi International University
-
Furuta Tomohisa
Department Of Biochemistry Fukushima Medical University
-
Tsuboi Masahiro
Department Of Neurological Surgery Okayama University Medical School
-
Tsuboi Masahiro
Department Of Diagnostic Radiology Tohoku University School Of Medicine
-
NORIKANE Hiroshi
Department of Neurological Surgery, Okayama University Medical School
-
Norikane Hiroshi
Department Of Neurological Surgery Okayama University Medical School
-
FURUTA Tomohisa
Department of Neurological Surgery, Okayama University Medical School
関連論文
- Coexistence of Cranial and Spinal Subdural Hematomas : Case Report
- Coexistence of Cranial and Spinal Subdural Hematomas : —Case Report—
- Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
- Significance of three-dimensional computed tomography in a very old patient with sigmoid volvulus
- 10. Cross-Spectral Analysis of the Thalamic and the Scalp EEG
- Altered Structure and Expression of the p53 Gene in Human Neuroepithelial Tumors
- Plain CT Findings of Brain Death Confirmed by Hollow Skull Sign in Brain Perfusion SPECT
- Photophobia as the Visual Manifestation of Chiasmal Compression by Unruptured Anterior Communicating Artery Aneurysm : Case Report
- Simultaneous Occurrence of Subarachnoid Hemorrhage Due to Ruptured Aneurysm and Remote Brainstem Hematoma
- S-A-6 S-A-6. The Relationship between the Enzymatic Activities of Human Brain Tumors and Clinical Features (Symposium A: Pathology and Biochemistry of Brain Tumors)
- 65 A Histochemical Study on Hydrolytic Enzymes and Dehydrogenases in Human Brain Tumoes
- Comparison of Screen-film and Full-field Digital Mammography in Japanese Population-based Screening
- Peritoneal Shunt Tube Migration Into the Stomach : Case Report
- Molecular Analysis of Astrocytoma Associated With Turcot Syndrome Type 1 : Case Report
- Adoptive Immunotherapy for Malignant Brain Tumors Using Human Peripheral Blood Mononuclear Cells Activated by the Streptococcal Preparation OK-432
- The Cytocidal Activity of OK-432-activated Mononuclear Cells against Human Glioma Cells is Partly Mediated through the Fas Ligand/Fas System
- Dural Arteriovenous Malformation Associated with Occlusion of the Superior Sagittal Sinus : Case Report
- Effects of Differential Hypothermia on Adenovirus Type 12 Induced Cheek Pouch Tumors : Histochemical Study of Hydrolytic and Glycolytic Enzymes
- Histologically Classified Venous Angiomas of the Brain : a Controversy
- 6. Ultrasonic Examination of Intracerebral Destructive Lesion in Stereotaxic Surgery : -The Third Report-
- 3. Ultrasonic Diagnosis of Brain Tumor by Dural Contact Compound Scope Method
- 12. Ultrasonic Examination of Intracerebral Destructive Lesion in Stereotaxic Surgery (The 2nd report) (PROCEEDINGS OF THE Vth ANNUAL MEETING OF THE JAPAN SOCIETY FOR RESEARCH IN STEREOENCEPHALOTOMY)
- Auditory Brainstem Responses before and after Shunting in Patients with Suspected Normal Pressure Hydrocephalus
- MR Imaging of Idiopathic Trigeminal Neuralgia: Correlation with Non-Surgical Therapy
- A Case of Brain Metastasis from Pulmonary Giant Cell Carcinoma
- Genetic alterations of human brain tumors as molecular prognostic factors
- A-48. Treatment of Malignant Brain Tumors by Differential Hypothermia.(5th report)
- B-19. Treatment of Malignant Brain Tumors by Differential Hypothermia : The 3rd Report
- A-67. The Ultrastructure of Pinealomas
- Neuropsychological Outcome and Social Recovery of Head-injured Patients
- Neuroendoscopic Transventricular Surgery for Suprasellar Cystic Mass Lesions Such as Cystic Craniopharyngioma and Rathke Cleft Cyst
- Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients
- Proliferative Potential and Apoptosis in Rat Glioma Cell Lines after Hyperthermia
- Influence of Extracellular Matrix on the Proliferation and Differentiation of Glioma Cells in Culture
- Expression of ICAD-L and ICAD-S in Human Brain Tumor and Its Cleavage upon Activation of Apoptosis by Anti-Fas Antibody
- 119 119. Studies on the Chronic Subdural Hematoma
- Operative Results of Ruptured Intracranial Aneurysms in Aged Patients
- Ret expression in the central nervous system
- Analysis of CD8 T-cell response by IFNγ ELISPOT and H-2L^d/pRL1a tetramer assays in pRL1a multiple antigen peptide-immunized and RL male 1-bearing BALB/c and (BALB/c×C57BL/6) F_1 mice
- New Method for the Evaluation of the Response of Cultured Cell Lines to Continuous Low-dose-rate Irradiation from Encapsulated Iridium-192 Seeds with Hyperthermia
- Thermal Damage Threshold of Brain Tissue : Histological Study of Heated Normal Monkey Brains
- Demonstration of Proliferating Cell Nuclear Antigen (PCNA/Cyclin) in Glioma Cells
- Early-stage lung cancer : diagnosis and treatment
- Treatment of Peripheral Early Stage Lung Cancer
- 5. Bronchoscopic Findings in a Case of Mustard Gas Poisoning
- 114. Surgical Treatment of Tumors of Pineal Region.
- Induction of Resistance to Etoposide and Adriamycin in a Human Glioma Cell Line Treated with Antisense Oligodeoxynucleotide Complementary to the Messenger Ribonucleic Acid of Deoxyribonucleic Acid Topoisomerase IIα
- Postoperative adjuvant therapy for completely resected early-stage non-small cell lung cancer
- 106 Forel-H-tomy for Epileptic Convulsion
- Immunocytochemical Approach to Virus-Induced Brain Tumors : From the Aspect of T (Tumor) Antigen
- Extraction of Bismuth(III) with 2-Bromoalkanoic Acid in Nondonating Solvent from Highly Acidic Aqueous Solution
- Observation of Positive/Negative Bands in a Polarized External Reflection Vis-Spectrum and the Orientation of Protonated Tetraphenylporphyrin Adsorbed at Liquid-Liquid Interface
- Extraction of Monomeric Species together with Dimeric Copper(II) 2-Bromoaliphatic and Conjugated Carboxylates in Benzene
- Measurement of External Reflection Spectra of Protonated Tetraphenylporphyrin Adsorbed at Liqued-Liquid Interface
- 27. Further Clinical and Physiological Observations on Stereotaxic Surgery for Involuntary Movements
- Present Strategy of Lung Cancer Screening and Surgical Management
- Combined Brachytherapy and External Beam Radiotherapy in Normal Monkey Brains : Experimental Radiation Necrosis Evaluated by Sequential Magnetic Resonance Imaging
- Effect of Adjuvant Iridium-192 Brachytherapy on the Survival of Patients with Malignant Gliomas
- Intracavernous Epidermoid Tumor Presenting with Abducens Nerve Paresis : Case Report
- Factors Influencing the Recurrence Rate of Intracranial Meningiomas after Surgery
- Familial Arteriovenous Malformations of the Brain : Two Case Reports
- Immunohistochemical Evidence for the Presence of S-100 Protein in Stromal Cells of Cerebellar Hemangioblastomas
- Resection of Deep-seated Gliomas Using Neuroimaging for Stereotactic Placement of Guidance Catheters
- Acute Effects of Interstitial Hyperthermia on Normal Monkey Brain : Magnetic Resonance Imaging Appearance and Effects on Blood-Brain Barrier
- Preliminary Results of Interstitial ^<192>Ir Brachytherapy for Malignant Gliomas
- 11. In Some Aspect of Electrical Stimulation of the Ventrolateral Nucleus and the Centromedian of the Human Thalamus
- 30. Statistical observation of acoustic neurinoma and facial nerve anastomosis.
- S-1. Evoked Cortical Responses afrer the Stimulation of Ventrolateral Nucleus of Numan Thalamus (Symposium:Human Depth Electrophysiology)
- Naturalized Epistemology and Its Problems
- Epistemology in Japan : 2000-2005
- Extracranial Vertebral Artery Aneurysm Causing Spinal Subarachnoid Hemorrhage : Case Report
- Cerebral Sinus Thrombosis in Patient with Ulcerative Colitis : Case Report
- A-4. Attempts of Measuring the Increment Rate of Water Contents in Edematous Brain Tissues by ^3H_2O-Liquid Scintillation Counter
- S-II-8. The Changes of CSF Dynamics and Normal Pressure Hydrocephalus Following Subarachnoid Hemorrhage
- 41. Stereotaxic Operation of Involuntary Movements.
- 19. Surgical Treatment for Hydrocephalus
- 104. Observations on cerebral hemispherectomy for infantile hemiplegia.
- Pineal regain tumor.
- A case of sacral cyst.
- Cerebral Vasospasm following Subarachnoid Hemorrhage : Experimental and Clinical Studies
- Hemifacial Spasm Due to Cerebellopontine Angle Epidermoid Tumor : Case Report
- Met-RANTES Ameliorates Fibrous Airway Obliteration and Decreases ERK Expression in a Murine Model of Bronchiolitis Obliterans
- The Present Status of Postoperative Adjuvant Chemotherapy for Completely Resected Non-Small Cell Lung Cancer
- Guidelines for Smoking Cessation (JCS 2010) : Digest Version
- Escherichia coli Pneumonia in Combination with Fungal Sinusitis and Meningitis in a Tsunami Survivor after the Great East Japan Earthquake
- Papillary adenoma of the lung with a peculiar raw macroscopic feature