Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
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概要
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NELL1 and NELL2 encode cysteine-rich amino acid sequences including six epidermal growth factor-like motifs, which contain signal peptides at the N-terminals. The deduced amino acid sequences of both genes are 55% identical and their cysteine stretch structures are conserved. NELL1 is expressed in the brain and kidney, whereas NELL2 is expressed specifically in the brain. The cell lineage expressing NELLs in the nervous system was investigated in established cell lines and central nervous system tumor tissues obtained from patients by Northern blot and reverse transcriptase-polymerase chain reaction analyses . NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. NELL1 and NELL2 were also expressed in central neurocytoma, medulloblastoma, and some astrocytic tumors. Immunohistochemical analysis revealed that NELL2 protein was localized in the cytoplasm of neurons. These results suggest that NELL2 is predominantly expressed in the neuronal cell lineage in the human nervous system. NELL1 is expressed mainly in tumor in the neuronal cell lineage.
- 日本脳神経外科学会の論文
- 2001-12-15
著者
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KATAGIRI Toyomasa
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, the University
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Katagiri Toyomasa
Laboratory Of Molecular Biosignal Research Center Kobe University School Of Medicine
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MAEDA Kenji
Departments of Biochemistry and Neurosurgery, Saga Medical School
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MATSUHASHI Sachiko
Departments of Biochemistry, Saga Medical School
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TABUCHI Kazuo
Department of Neurosurgery, Saga Medical School
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WATANABE Takeshi
Otsuka GEN Research Institute, Otsuka Pharmaceutical Co. Ltd.
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OYASU Miho
Laboratory of Molecular Biosignal Research Center, Kobe University, School of Medicine
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SAITO Naoki
Laboratory of Molecular Biosignal Research Center, Kobe University, School of Medicine
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KURODA Shun-ichi
Institute of Scientific and Industrial Research, School of Medicine, Osaka University
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Tabuchi Kazuo
Department Of Neurological Surgery Okayama University Medical School
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Matsuhashi Sachiko
Departments Of Biochemistry Saga Medical School
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Matsuhashi Sachiko
Department Of Biochemistry Division Of Urology Saga Medical School
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Oyasu Miho
Laboratory Of Molecular Biosignal Research Center Kobe University School Of Medicine
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Kuroda Shun-ichi
Institute Of Scientific And Industrial Research School Of Medicine Osaka University
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Saito Naoki
Laboratory Of Molecular Biosignal Research Center Kobe University School Of Medicine
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Watanabe Takeshi
Otsuka Gen Research Institute Otsuka Pharmaceutical Co. Ltd.
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Maeda Kenji
Departent Of Cardiology Kobe General Hospital
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Maeda Kenji
Departments Of Biochemistry And Neurosurgery Saga Medical School:(present Address)department Of Neur
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