Influence of Extracellular Matrix on the Proliferation and Differentiation of Glioma Cells in Culture
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概要
- 論文の詳細を見る
The influence of extracellular matrix on the proliferation and differentiation of glioma cells in vitro was investigated by culturing glioma cells in collagen gel and on collagen and laminin films. Rat C-6 glioma cells extended thin cytoplasmic processes, proliferated, and differentiated in collagen gel and on collagen film. The cells were stellate with multiple thin processes like the astrocyte in vivo. The intracellular content of cyclic adenosine-monophosphate in rat C-6 glioma cells on collagen film increased approximately four fold over the control level. In laminin film culture, rat C-6 glioma cells extended thin cytoplasmic processes with many knotty structures and proliferated. These findings confirm that extracellular matrix induces the differentiation of glioma cells.
- 日本脳神経外科学会の論文
- 1991-09-15
著者
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TABUCHI Kazuo
Department of Neurosurgery, Saga Medical School
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SUGIHARA HAJIME
Department of Pathology, International University of Health and Welfare
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Tabuchi Kazuo
Department Of Neurological Surgery Okayama University Medical School
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Tabuchi Kazuo
Department Of Neurosurgery Saga Medical School
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Sugihara Hajime
Department Of Pathology Saga Medical School
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Sugihara Hajime
Department Of Pathology And Biodefense Xxxx Faculty Of Medicine Saga University
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TAKAGI Masashi
Department of Neurosurgery, Fukuoka Wajiro Hospital
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Takagi Masashi
Department Of Neurosurgery Saga Medical School
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Takagi Masashi
Department Of Neurosurgery Fukuoka Wajiro Hospital
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