Adoptive Immunotherapy for Malignant Brain Tumors Using Human Peripheral Blood Mononuclear Cells Activated by the Streptococcal Preparation OK-432
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概要
- 論文の詳細を見る
Adoptive immunotherapy using OK-432-activated mononuclear cells (OK-MCs) offers cell-mediated and cytokine-mediated pathways for antitumor activity. The effectiveness of direct intratumoral administration of OK-MCs via a catheter/reservoir system was studied in patients with malignant brain tumors. Seventeen patients, 12 with malignant glioma, four with metastatic adenocarcinoma, and one with primary sarcoma of the brain, were treated by OK-MC therapy (1.0 to 11.2 x 10^7 cells/person) between June 1989 and April 1999. The OK-MC therapy was given to patients with tumors progressing despite previous cytoreductive surgery, radiation, or chemotherapy. Adverse effects seen after the therapy were fever in 10 patients, seizure in two patients, and hypotension in one patient. Evaluation by computed tomography or magnetic resonance imaging revealed that seven patients showed no change including three with minor response, and 10 showed progressive disease. Adoptive immunotherapy using OK-MC was safe and well tolerated, but the therapeutic potential is limited.
- 日本脳神経外科学会の論文
- 2001-08-15
著者
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MINETA Toshihiro
Department of Neurosurgery, Saga University, Faculty of Medicine
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Mineta Toshihiro
佐賀大学 医学部脳神経外科
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Mineta T
Department Of Neurosurgery Faculty Of Medicine Saga University
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Mineta Toshihiro
Department Of Neurosurgery Saga Medical School
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TABUCHI Kazuo
Department of Neurosurgery, Saga Medical School
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TODA Keisuke
Department of Neurosurgery Institute of Neurosciences, St. Mary's Hospital
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Toda Keisuke
Department Of Neurosurgery Institute Of Neurosciences St. Mary's Hospital
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Tabuchi Kazuo
小柳記念病院 脳神経外科
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Tabuchi K
Department Of Neurosurgery Saga Medical School
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Tabuchi Kazuo
Department Of Neurological Surgery Okayama University Medical School
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Tabuchi K
Department Of Neurosurgery Kagawa Medical School
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FUKUYAMA Kouzou
Department of Neurosurgery Saga Medical School
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ICHINOSE Makoto
Department of Neurosurgery, Saga Medical School
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HIROTSU Tatsumi
Department of Neurosurgery, Saga Medical School
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Ichinose Makoto
Department Of Neurosurgery Saga Medical School
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Hirotsu Tatsumi
Department Of Neurosurgery Saga Medical School
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Mineta Toshihiro
Department Of Neurosurgery Faculty Of Medicine Saga University
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