Thermal Damage Threshold of Brain Tissue : Histological Study of Heated Normal Monkey Brains
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概要
- 論文の詳細を見る
The thermal damage threshold of normal brain tissue was evaluated from immediate and delayed histological changes caused by hyperthermia treatment of normal monkey (Macaca fuscata) brains. A 2450MHz microwave antenna and an antenna cooling system devised by our group were used for interstitial hyperthermia treatment. The antenna within the cooling system was inserted through a small craniectomy under general anesthesia. The temperature at a reference point, 4mm radially away from the surface of the cooling system, was maintained at 42, 43, 44, 45, or 46℃ for 60 minutes. Eighteen animals were treated and sacrificed immediately after the treatment, while nine animals were treated and sacrificed 7 days after the treatment. The histological changes were studied microscopically on sections stained with HE or Kluver-Barrera's method. The non-survival experiment demonstrated that areas heated at 44℃ or below showed no obvious irreversible changes. The survival experiment showed areas heated at 44℃ or above developed coagulative necrosis. These histological findings indicate that thermal damage occurs in normal brain tissue after heating at 44℃ or above for 60 minutes, suggesting that the safety limit for brain hyperthermia is 43℃ for 60 minutes.
- 日本脳神経外科学会の論文
- 1994-04-15
著者
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松本 健五
信州大学 脳神経外科
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Matsumoto Kengo
Department of Cardiology, National Hospital Organization Kure Medical Center, Chugoku Cancer Center
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NISHIMOTO Akira
Department of Neurological Surgery,Okayama University Medical School
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Nishimoto Akira
Department Of Neurological Surgery Okayama University Medical School
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Nishimoto Akira
Department Of Neurosurgery Kagawa Rosai Hospital
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Matsumoto Kengo
Department Of Cardiology National Hospital Organization Kure Medical Center
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FURUTA Tomohisa
Department of Clinical Psychology, School of Social Welfare, Kibi International University
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MATSUMI Nobuhiko
Department of Neurological Surgery, Okayama University Medical School
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MISHIMA Nobuya
Department of Neurological Surgery, Okayama University Medical School
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MORIYAMA Eiji
Department of Neurological Surgery, Okayama University Medical School
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TAGUCHI Kohji
Department of Clinical Pathology, Okayama University Hospital
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Furuta Tomohisa
Department Of Neurological Surgery Okayama University Medical School
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Furuta Tomohisa
Department Of Biochemistry Fukushima Medical University
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Moriyama Eiji
Department Of Neurological Surgery Okayama University Medical School
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Taguchi Kohji
Department Of Clinical Pathology Okayama University Hospital
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Mishima Nobuya
Department Of Neurological Surgery Okayama University Medical School
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Matsumi Nobuhiko
Department Of Neurological Surgery Okayama University Medical School
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FURUTA Tomohisa
Department of Neurological Surgery, Okayama, University Medical School
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