Anti-inflammatory Effect of D-Allose in Cerebral Ischemia/Reperfusion Injury in Rats
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概要
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D-allose, a type of rare sugar, can produce inhibitory effects on activated leukocytes in various organs, including immunosuppressive effects and anti-inflammatory effects, as well as anti-oxyradical effects. The present experiment was performed to investigate the potential anti-inflammatory effects of D-allose in acute cerebral ischemia/reperfusion (I/R) injury. Transient middle cerebral artery occlusion model was applied in rats. D-allose was administered two times via a tail vein (300 mg/kg, 1 hour before ischemia and 10 hours after reperfusion). After 22 hours of reperfusion following 2 hours of ischemia, brain damage was evaluated by cerebral infarct volume. Myeloperoxidase (MPO) activity assay by enzyme-linked immunosorbent assay, and protein expression of MPO and cyclooxygenase-2 (COX-2) by immunohistochemistry were evaluated to investigate the potential mechanisms of D-allose. The experimental results showed that D-allose exhibited significant neuroprotective effects against acute cerebral I/R injury. The infarct volume in D-allose-treated rats (90.9 ± 13.5 mm3) was significantly smaller than that in vehicle rats (114.9 ± 15.3 mm3, p < 0.01). D-allose treatment significantly suppressed the MPO activity and the number of MPO-positive cells compared with those in the vehicle group, suggesting that treatment with D-allose can reduce the infiltration of leukocytes into the ischemic tissue. Treatment of D-allose also significantly decreased the number of COX-2-positive cells and microglial activation in the ischemic tissue. The present results demonstrate that D-allose exerts potent neuroprotective effects against acute cerebral I/R injury, and constitute the first evidence of anti-inflammatory effects of D-allose which considerably contributes to the beneficial effects. Treatment with D-allose might provide a new strategy and clinically beneficial outcome for acute ischemic stroke.
著者
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TAMIYA Takashi
Department of Neurological Surgery, Kagawa University Faculty of Medicine
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Nakamura Takehiro
Department Of Applied Chemistry Faculty Of Science And Technology Keio University
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Tamiya Takashi
Department Of Neurological Surgery Faculty Of Medicine Kagawa University
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Kawai Nobuyuki
Department Of Medical Physics Faculty Of Medicine Kagawa University
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Lu Feng
Department Of Epidemiology And Biostatistics Moe Key Laboratory Of Modern Toxicology School Of Public Health Cancer Center Nanjing Medical University
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LU Feng
Department of Neurobiology, Kagawa University Faculty of Medicine
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GAO Dakuan
Department of Neurological Surgery, Kagawa University Faculty of Medicine
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FEI Zhou
Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University
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