Treatment of Malignant Glioma with High Dose Intra-arterial ACNU and Autologous Bone Marrow Transplantation : Case Report
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概要
- 論文の詳細を見る
A 44-year-old female with malignant astrocytoma received subtotal removal and high dose (200 mg/m^2) intra-arterial 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) with autologous bone marrow transplantation. Tumor remission with minimal bone marrow suppression was achieved. However, she developed severe encephalopathy and computed tomographic scans revealed a low-density area at the ACNU delivery site. She received glycerol solution to treat the brain edema and recovered completely from the encephalopathy. Intra-arterial ACNU exceeding 200 mg/m^2 possibly causes neurotoxicity.
- 日本脳神経外科学会の論文
- 1991-10-15
著者
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Yoshioka Junji
Department Of Neurological Surgery Kagawa Medical School
-
Fujiwara Takashi
Department Of Electrical And Electronic Systems Engineering Graduate School Of Information Science A
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Fujiwara Takashi
Department Of Neurological Surgery Kagawa Medical School
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Ohmoto Takashi
Department Of Neurological Surgery Kagawa Medical School
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OHMOTO Takashi
Department of Environmental Technology, Osaka Municipal Technical Research Institute
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