A rat paclitaxel model does not develop thermal hyperalgesia
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概要
- 論文の詳細を見る
We previously a rat sciatic neuropathy model using paclitaxel developed cold-allodynia. Cold-allodynia is thought to result from degradation of Aδ or C fibers. We investigated which nerves are involved by measuring thermal hyperalgesia. Thermal hyperalgesia did not develop and the C fibers appeared normal. Based on our findings, local administration of paclitaxel caused nerve degeneration of only myelinated Aδ and Aβ fibers, such as demyelination. The effect on unmyelinated nerves (C fibers) may be low. (J Osaka Dent Univ 2003; 37: 115-117.)
- 大阪歯科学会の論文
著者
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Kotani Junichiro
Department of Anesthesiology, Osaka Dental University
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Kotani Junichiro
Osaka Dental Univ. Osaka Jpn
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Kotani J
Department Of Anesthesiology Osaka Dental University
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Kotani Junichiro
Department Of Anesthesiology Osaka Dental University
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SAKUMA Yasushi
Department of Anesthesiology,Osaka Dental University
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Sakuma Yasushi
Osaka Dental Univ. Osaka Jpn
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Sakuma Yasushi
Department Of Anesthesiology Osaka Dental University
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Kato Yasuhiko
Department of Anesthesiology, Osaka Dental University
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Hashimoto Kayoko
Graduate School of Dentistry(Anesthesiology), Osaka Dental University
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Hashimoto kayoko
Department of Anesthesiology, Osaka Dental University
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Kan Yuki
Graduate School Of Dentistry (anesthesiology) Osaka Dental University
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Kato Yasuhiko
Department Of Anesthesiology Osaka Dental University
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Hashimoto Kayoko
Department Of Anesthesiology Osaka Dental University
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