Effect of propofol on vascular absorption of local anesthetics containing adrenalin

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We investigated the influence of propofol, which has peripheral vasodilative action, on vascular absorption of local anesthetics in an animal experiment. Propofol was infused intravenously in 18 rabbits at a rate of 45mg/kg/h to achieve sedation under spontaneous respiration. Lidocaine (6mg/kg) was used as the local anesthetic. The rabbits were randomly divided into three groups of six animals each and received submucosal infiltration of the following drugs in the lower lip: lidocaine without adrenalin (Group L), lidocaine with 1:160,000 adrenalin (Group LA-L), or lidocaine with 1:80,000 adrenalin (Group LA-H). Arterial blood lidocaine concentrations were measured at regular intervals. The plasma lidocaine concentrations of Group LA-L and Group LA-H were lower than those of Group L for the first 30 minutes after administration. These results suggest that sustaining the vascular absorption inhibition effect of adrenalin was caused by vasoconstriction despite propofol administration. On the other hand, no difference was observed in plasma lidocaine concentrations between Group LA-L and Group LA-H, suggesting that both had a similar degree of vascular absorption. In conclusion, propofol is thought to have peripheral vasodilative action that offsets the concentration-dependent vasoconstriction of adrenalin.
大阪歯科学会の論文